Adolescents and young adults with brain tumors in the context of molecular advances in neuro-oncology
Jazyk angličtina Země Spojené státy americké Médium print-electronic
Typ dokumentu časopisecké články, přehledy
PubMed
29049858
DOI
10.1002/pbc.26861
Knihovny.cz E-zdroje
- Klíčová slova
- adolescents and young adults, brain tumor, glioma, pediatric,
- MeSH
- chemorezistence genetika MeSH
- dospělí MeSH
- individualizovaná medicína metody trendy MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- nádory mozku diagnóza genetika terapie MeSH
- prognóza MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
Adolescents and young adults (AYA) comprise a specific group of oncology patients with a distinct biological and epidemiological spectrum of central nervous system neoplasms. It has been well documented that they differ clinically, especially in relation to prognosis and chemotherapy tolerance; however, the underlying reasons for this are unclear. Recent advances in the genomics of both childhood and adult brain tumors have provided new explanations and insights into the previously described age-dependent heterogeneity. Herein, we summarize the current state of the AYA population in neuro-oncology, specifically how biological advances can help personalize therapy for this unique group of patients.
Division of Hematology Oncology Hospital for Sick Children University of Toronto Toronto ON Canada
Pediatric Hematology Oncology Department Hospital Niño Jesús Madrid Spain
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