Adolescents and young adults with brain tumors in the context of molecular advances in neuro-oncology
Language English Country United States Media print-electronic
Document type Journal Article, Review
PubMed
29049858
DOI
10.1002/pbc.26861
Knihovny.cz E-resources
- Keywords
- adolescents and young adults, brain tumor, glioma, pediatric,
- MeSH
- Drug Resistance, Neoplasm genetics MeSH
- Adult MeSH
- Precision Medicine methods trends MeSH
- Humans MeSH
- Adolescent MeSH
- Young Adult MeSH
- Brain Neoplasms diagnosis genetics therapy MeSH
- Prognosis MeSH
- Check Tag
- Adult MeSH
- Humans MeSH
- Adolescent MeSH
- Young Adult MeSH
- Male MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Review MeSH
Adolescents and young adults (AYA) comprise a specific group of oncology patients with a distinct biological and epidemiological spectrum of central nervous system neoplasms. It has been well documented that they differ clinically, especially in relation to prognosis and chemotherapy tolerance; however, the underlying reasons for this are unclear. Recent advances in the genomics of both childhood and adult brain tumors have provided new explanations and insights into the previously described age-dependent heterogeneity. Herein, we summarize the current state of the AYA population in neuro-oncology, specifically how biological advances can help personalize therapy for this unique group of patients.
Division of Hematology Oncology Hospital for Sick Children University of Toronto Toronto ON Canada
Pediatric Hematology Oncology Department Hospital Niño Jesús Madrid Spain
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