Tungsten (VI) based "molecular puzzle" photoluminescent nanoparticles easily covered with biocompatible natural polysaccharides via direct chelation
Jazyk angličtina Země Spojené státy americké Médium print-electronic
Typ dokumentu časopisecké články
PubMed
29078182
DOI
10.1016/j.jcis.2017.10.056
PII: S0021-9797(17)31215-8
Knihovny.cz E-zdroje
- Klíčová slova
- Adsorption of polysaccharides, Doped calcium tungstate nanoparticles, HepG2 cell targeting, Tungsten oxide nanoparticles,
- MeSH
- biokompatibilní materiály chemie MeSH
- buňky Hep G2 MeSH
- endocytóza fyziologie MeSH
- konfokální mikroskopie MeSH
- lidé MeSH
- luminiscence * MeSH
- nanočástice aplikace a dávkování chemie účinky záření MeSH
- polysacharidy chemie MeSH
- terbium chemie MeSH
- wolfram chemie MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- biokompatibilní materiály MeSH
- polysacharidy MeSH
- terbium MeSH
- wolfram MeSH
Multimodal probes, which can be simultaneously visualized by multiple imaging modalities, enable the cellular uptake, intracellular fate, biodistribution and elimination to be tracked in organisms. In this study, we report the synthesis of crystalline WO3 and CaWO4 doped with Eu3+ or Tb3+ nanoparticles (size range of 10-160 nm) coated with polysaccharides, and these nanoparticles constitute a versatile easy-to-construct modular toolbox for multimodal imaging. The particles adsorb significant amounts of polysaccharides from the solution, providing biocompatibility and may serve as a platform for labeling. For WO3, the sorption is reversible. However, on CaWO4, stable coating is formed. CaWO4/Tb3+ coated with chemisorbed dextrin, mannan, guar gum and sodium alginate successfully underwent endocytosis with HepG2 cells and was visualized using confocal microscopy.
Institute for Clinical and Experimental Medicine Vídeňská str 1958 9 140 21 Prague 4 Czech Republic
Institute of Macromolecular Chemistry AS CR Heyrovsky Sq 1888 2 162 06 Prague 6 Czech Republic
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