Hand osteoarthritis (OA) is a common degenerative joint disorder leading to substantial pain and disability. The most severe subtype is erosive hand OA characterized by an abrupt onset, local inflammation, subchondral erosions and worse outcomes than non-erosive disease. Biomarkers of hand OA could help to diagnose the disease earlier, to distinguish patients with erosive and non-erosive forms, to assess disease severity or to predict its future progression. The objective of this review was to summarize the role of potential biomarkers of hand OA. A PubMed search for soluble biomarkers associated with hand OA was performed from inception to June 2017. In total, 21 relevant publications were found and reviewed. These publications identified 20 potential biomarkers of hand OA. C-terminal cross-linking telopeptide of type II collagen, cartilage oligomeric matrix protein, osteocalcin, hyaluronan, urinary pentosidine, vascular cell adhesion molecule 1, monocyte chemotactic protein 1, osteoprotegerin and interleukin 1 have been shown as potential biomarkers for assessing disease severity. C-terminal cross-linking telopeptide of type I collagen, hyaluronan, urinary pentosidine and myeloperoxidase were shown to differentiate between erosive and non-erosive hand OA patients. A number of biomarkers reflecting joint tissue metabolism and inflammation have been studied in hand OA. Some were identified as potential biomarkers of disease severity and progression, others were shown to differentiate between erosive and non-erosive disease. However, further research is necessary to assess the value of biomarkers for use in clinical practice.

Department of Rheumatology 1st Faculty of Medicine Charles University Prague Czech Republic

Institute of Rheumatology Na Slupi 4 12850 Prague 2 Czech Republic

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Nat Rev Rheumatol. 2011 Jan;7(1):33-42 PubMed

Int J Biochem Cell Biol. 2009 May;41(5):998-1001 PubMed

Clin Pharmacol Ther. 2001 Mar;69(3):89-95 PubMed

J Biol Chem. 1998 Aug 7;273(32):20397-403 PubMed

Osteoarthritis Cartilage. 2006 Aug;14 (8):723-7 PubMed

Biochim Biophys Acta. 2006 Aug;1762(8):711-8 PubMed

Osteoarthritis Cartilage. 2009 Dec;17 (12 ):1615-9 PubMed

Osteoarthritis Cartilage. 2016 Jan;24(1):9-20 PubMed

J Biol Chem. 1997 Apr 11;272(15):9755-63 PubMed

J Orthop Res. 2007 Sep;25(9):1128-35 PubMed

J Biol Chem. 1990 Jun 25;265(18):10334-9 PubMed

Osteoarthritis Cartilage. 2004 Apr;12 (4):277-83 PubMed

Rheumatology (Oxford). 2016 Sep;55(9):1585-93 PubMed

J Biol Chem. 2007 Aug 24;282(34):24591-8 PubMed

Cell. 2007 Aug 10;130(3):456-69 PubMed

Arthritis Rheum. 2011 Nov;63(11):3383-91 PubMed

Cell. 1997 Apr 18;89(2):309-19 PubMed

FEBS Lett. 1994 Nov 7;354(2):237-40 PubMed

Ann Rheum Dis. 2014 Feb;73(2):365-75 PubMed

Osteoarthritis Cartilage. 2005 Mar;13(3):258-65 PubMed

Osteoarthritis Cartilage. 2001 Nov;9(8):720-6 PubMed

J Biol Chem. 2001 Feb 23;276(8):6046-55 PubMed

J Biol Chem. 2011 Dec 16;286(50):43250-8 PubMed

Ann Rheum Dis. 2011 Jul;70(7):1282-4 PubMed

J Orthop Traumatol. 2008 Jun;9(2):81-7 PubMed

J Hum Genet. 2003;48(5):222-5 PubMed

J Intern Med. 1997 Jul;242(1):27-33 PubMed

Osteoarthritis Cartilage. 2006 Jul;14(7):690-5 PubMed

Arthritis Rheum. 1999 May;42(5):1003-9 PubMed

Joint Bone Spine. 2012 Mar;79(2):160-5 PubMed

Int J Tissue React. 2003;25(1):25-8 PubMed

Curr Opin Rheumatol. 2013 Jan;25(1):136-44 PubMed

Arch Biochem Biophys. 1997 May 1;341(1):8-16 PubMed

Mol Biol Rep. 2010 Oct;37(7):3265-72 PubMed

Ann Rheum Dis. 2005 Jun;64(6):955-7 PubMed

J Biol Chem. 1992 Nov 5;267(31):22346-50 PubMed

J Biol Chem. 2005 Sep 23;280(38):32655-61 PubMed

J Biol Chem. 2007 Oct 26;282(43):31166-73 PubMed

Osteoarthritis Cartilage. 2008 Sep;16(9):1054-9 PubMed

J Biol Chem. 1978 Dec 25;253(24):9063-8 PubMed

Arthritis Rheum. 2001 May;44(5):985-94 PubMed

Clin Exp Rheumatol. 2011 May-Jun;29(3):544-6 PubMed

Curr Genomics. 2015 Dec;16(6):419-26 PubMed

Proc Natl Acad Sci U S A. 1976 May;73(5):1447-51 PubMed

J Immunol Methods. 2004 Nov;294(1-2):145-53 PubMed

Osteoarthritis Cartilage. 2012 Jun;20(6):557-61 PubMed

Ann Rheum Dis. 2009 Jan;68(1):8-17 PubMed

Arthritis Rheum. 1999 Jul;42(7):1443-50 PubMed

Arthritis Rheum. 1999 Mar;42(3):483-9 PubMed

Cell. 2011 Mar 4;144(5):796-809 PubMed

Arthritis Rheum. 2010 Jul;62(7):1993-2003 PubMed

J Cell Biol. 1991 Sep;114(6):1307-19 PubMed

Physiol Res. 2002;51(2):139-44 PubMed

J Rheumatol. 2014 May;41(5):938-44 PubMed

J Biol Chem. 1980 Sep 25;255(18):8685-91 PubMed

Ann Rheum Dis. 2017 Jan;76(1):214-217 PubMed

Bone. 2001 Sep;29(3):209-15 PubMed

J Clin Invest. 1997 Apr 1;99(7):1534-45 PubMed

Osteoarthritis Cartilage. 2016 Apr;24(4):573-80 PubMed

Eur J Appl Physiol Occup Physiol. 1998 Nov;78(6):573-7 PubMed

J Biol Chem. 1976 Mar 10;251(5):1371-4 PubMed

Ann Rheum Dis. 2005 May;64(5):682-7 PubMed

Ann Rheum Dis. 2013 Nov;72(11):1756-63 PubMed

Osteoarthritis Cartilage. 2010 Nov;18(11):1448-53 PubMed

Proc Natl Acad Sci U S A. 1980 Apr;77(4):2234-8 PubMed

Nat Rev Rheumatol. 2016 May;12(5):296-302 PubMed

Am J Epidemiol. 2002 Dec 1;156(11):1021-7 PubMed

Ann Rheum Dis. 2009 Feb;68(2):295-6 PubMed

Br J Rheumatol. 1997 Nov;36(11):1151-60 PubMed

Am J Hum Genet. 1998 Feb;62(2):311-9 PubMed

J Biol Chem. 2000 Nov 3;275(44):34681-92 PubMed

Rheumatology (Oxford). 2016 Apr;55(4):680-8 PubMed

Ann Rheum Dis. 2006 Mar;65(3):360-5 PubMed

Arthritis Res Ther. 2011;13(6):R184 PubMed

Rheumatol Int. 2010 Jun;30(8):1131-5 PubMed

Clin Exp Rheumatol. 2016 Nov-Dec;34(6):991-998 PubMed

Clin Chem. 1994 Nov;40(11 Pt 1):2022-5 PubMed

Rheumatology (Oxford). 2013 Feb;52(2):400-2 PubMed

J Biol Chem. 1992 Mar 25;267(9):6132-6 PubMed

Osteoarthritis Cartilage. 2007 May;15(5):516-23 PubMed

Open Rheumatol J. 2012;6:64-9 PubMed

PLoS One. 2012;7(10 ):e47860 PubMed

Mediators Inflamm. 2009;2009:345838 PubMed

Osteoarthritis Cartilage. 2004 Oct;12(10):843-5 PubMed

J Bone Miner Res. 1997 Jul;12(7):1028-34 PubMed

Nature. 1996 Aug 1;382(6590):448-52 PubMed

Dev Dyn. 1995 Jun;203(2):198-211 PubMed

Ann Rheum Dis. 1994 Jan;53(1):8-13 PubMed

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