Biphasic papillary renal cell carcinoma is a rare morphological variant with frequent multifocality: a study of 28 cases
Jazyk angličtina Země Anglie, Velká Británie Médium print-electronic
Typ dokumentu časopisecké články
PubMed
29119638
DOI
10.1111/his.13432
Knihovny.cz E-zdroje
- Klíčová slova
- alveolar, biphasic, immunohistochemistry, kidney, papillary renal cell carcinoma, solid variant of papillary renal cell carcinoma, squamoid,
- MeSH
- dospělí MeSH
- karcinom z renálních buněk patologie MeSH
- lidé středního věku MeSH
- lidé MeSH
- nádorové biomarkery analýza MeSH
- nádory ledvin patologie MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- nádorové biomarkery MeSH
AIMS: To further characterise biphasic squamoid renal cell carcinoma (RCC), a recently proposed variant of papillary RCC. METHODS AND RESULTS: We identified 28 tumours from multiple institutions. They typically showed two cell populations-larger cells with eosinophilic cytoplasm and higher-grade nuclei, surrounded by smaller, amphophilic cells with scanty cytoplasm. The dual morphology was variable (median 72.5% of tumour, range 5-100%); emperipolesis was found in all cases. The male/female ratio was 2:1, and the median age was 55 years (range 39-86 years). The median tumour size was 20 mm (range 9-65 mm). Pathological stage pT1a was found in 21 cases, pT1b in three, and pT3a and pT3b in one each (two not available). Multifocality was found in 32%: multifocal biphasic RCC in one case, biphasic + papillary RCC in two cases, biphasic + clear cell RCC in three cases, biphasic + low-grade urothelial carcinoma of the renal pelvis in one case, and biphasic + Birt-Hogg-Dubé syndrome in one case. Positive immunostains included: PAX8, cytokeratin (CK) 7, α-methylacyl-CoA racemase, epithelial membrane antigen, and vimentin. Cyclin D1 was expressed only in the larger cells. The Ki67 index was higher in the larger cells (median 5% versus ≤1%). Negative stains included: carbonic anhydrase 9, CD117, GATA-3, WT1, CK5/6, and CK20; CD10 and 34βE12 were variably expressed. Gains of chromosomes 7 and 17 were found in two evaluated cases. Follow-up was available for 23 patients (median 24 months, range 1-244 months): 19 were alive without disease, one was alive with recurrence, and one had died of disease (two had died of other causes). CONCLUSIONS: Biphasic papillary RCC is a rare variant of papillary RCC, and is often multifocal.
Calgary Laboratory Services and University of Calgary Rockyview General Hospital Calgary AB Canada
Centre de Biologie Pathologie Lille France
Charles University Pilsen Czech Republic
CHU Pontchaillou Rennes France
Cleveland Clinic Cleveland OH USA
Cruces University Hospital BioCruces Institute University of the Basque Country Bizkaia Spain
Friedrich Alexander University Erlangen Germany
Henry Ford Health System Detroit MI USA
Jordan University of Science and Technology Irbid Jordan
McGill University Montreal QC Canada
Tissupath Melbourne Vic Australia
University Clinical Hospital Centre Sestre Milosrdnice Zagreb Croatia
Citace poskytuje Crossref.org
Molecular Genetics of Renal Cell Tumors: A Practical Diagnostic Approach