Paraneoplastic neuromyelitis optica spectrum disorder: A case report and review of the literature
Language English Country Scotland Media print-electronic
Document type Case Reports, Journal Article, Review
PubMed
29133107
DOI
10.1016/j.jocn.2017.10.030
PII: S0967-5868(17)31075-5
Knihovny.cz E-resources
- Keywords
- Aquaporin-4, Neuromyelitis optica, Paraneoplastic,
- MeSH
- Aquaporin 4 immunology MeSH
- Autoantibodies analysis blood cerebrospinal fluid MeSH
- Immunohistochemistry MeSH
- Smoking MeSH
- Humans MeSH
- Magnetic Resonance Imaging MeSH
- Lung Neoplasms complications MeSH
- Neuromyelitis Optica complications diagnostic imaging therapy MeSH
- Paraneoplastic Polyneuropathy diagnostic imaging etiology therapy MeSH
- Spine diagnostic imaging MeSH
- Aged MeSH
- Carcinoma, Squamous Cell complications MeSH
- Check Tag
- Humans MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Case Reports MeSH
- Review MeSH
- Names of Substances
- Aquaporin 4 MeSH
- AQP4 protein, human MeSH Browser
- Autoantibodies MeSH
Neuromyelitis optica spectrum disorders (NMOSD) are demyelinating, autoimmune diseases affecting the central nervous system. Typically, recurrent optic neuritis and longitudinal extensive transverse myelitis dominates the clinical picture. In most cases NMOSD are associated with autoantibodies targeting the water channel aquaporin-4 (AQP-4). NMOSD usually present in young adults. Clinical findings suggestive of NMOSD in elderly patients should raise the suspicion of a paraneoplastic etiology. To our knowledge, we report the first case of a 66 year-old female patient with paraneoplastic NMOSD that is associated with squamous cell lung carcinoma. Anti-AQP-4 was present in both the serum and cerebrospinal fluid of the patient. However, immunhistological staining of the malignant tissue did not show presence of AQP-4 on the surface of tumour cells.
Department of Neurology Faculty of General Medicine University of Szeged Szeged Hungary
Department of Pathology Faculty of General Medicine University of Szeged Szeged Hungary
Institute of Neurology Medical University of Vienna Vienna Austria
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