Serum Vitamin D Status, Vitamin D Receptor Polymorphism, and Glucose Homeostasis in Healthy Subjects
Language English Country Germany Media print-electronic
Document type Journal Article
PubMed
29183090
DOI
10.1055/s-0043-122144
Knihovny.cz E-resources
- MeSH
- Adult MeSH
- Glucose metabolism MeSH
- Homeostasis * MeSH
- Insulin Resistance genetics MeSH
- Polymorphism, Single Nucleotide genetics MeSH
- Middle Aged MeSH
- Humans MeSH
- Multivariate Analysis MeSH
- Cross-Sectional Studies MeSH
- Receptors, Calcitriol genetics MeSH
- Risk Factors MeSH
- Aged MeSH
- Vitamin D analogs & derivatives blood MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- 25-hydroxyvitamin D MeSH Browser
- Glucose MeSH
- Receptors, Calcitriol MeSH
- VDR protein, human MeSH Browser
- Vitamin D MeSH
Low vitamin D status has been frequently associated with impaired glucose metabolism. We examined associations between 25-hydroxyvitamin D (25-OH-D) and several parameters of glucose homeostasis in virtually healthy subjects, and explored possible interaction with vitamin D receptor (VDR) polymorphism. Nondiabetic subjects without chronic medication or any known significant manifest disease were selected from large general-population based population survey. Insulin sensitivity and β cell secretion were calculated by homeostasis model assessment (HOMA) and soluble isoform of receptor for advanced glycation end-products (sRAGE) using commercial ELISA. Subjects were also genotyped for rs2228570 polymorphism of VDR. After adjustment for potential confounders, we observed a significant relationship between 25-OH-D and fasting glycemia (β coefficient=-5.904; p=0.002) or insulin sensitivity (β=0.042; p=0.001), but not with β cell secretion or sRAGE. We found also an interaction with VDR polymorphism. Subjects with low 25-OH-D and AA genotype had significantly lower insulin sensitivity than those with GG genotype plus highest 25-OH-D concentrations (107.3% vs. 183.9%, p=0.021). In conclusion, low vitamin D status was in virtually healthy subjects associated with decreased insulin sensitivity, namely in those with GG genotype of rs2228570 VDR polymorphism.
Biomedical Center Medical Faculty of Charles University Pilsen Czech Republic
Department of Biology Medical Faculty of Charles University Pilsen Czech Republic
Department of Immunodiagnostics University Hospital Pilsen Czech Republic
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