In vivo study on biodegradable magnesium alloys: Bone healing around WE43 screws
Language English Country Great Britain, England Media print-electronic
Document type Journal Article
- Keywords
- Biodegradable magnesium alloys, WE43 bone healing, bone healing, in vivo study, rabbit tibia,
- MeSH
- Magnesium adverse effects chemistry MeSH
- Bone Screws * adverse effects MeSH
- Rabbits MeSH
- Surface Properties MeSH
- Alloys adverse effects chemistry MeSH
- Tibia injuries pathology surgery MeSH
- Titanium adverse effects chemistry MeSH
- Absorbable Implants * adverse effects MeSH
- Animals MeSH
- Check Tag
- Rabbits MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Magnesium MeSH
- Alloys MeSH
- Titanium MeSH
Introduction A standard osteosynthetic material for maxillofacial skeleton is titanium and its alloys. The convenience of degradable material is avoiding of second surgery in cases, where removal of the material is necessary. Magnesium biodegradable alloys have similar mechanic properties as cortical bone - reasonable corrosion and sufficient biologic properties. They might be used in facial skeleton fixation. Materials and methods The study included a total of 16 rabbits, and they were randomly divided into two groups. Each group received two screws (WE4 and titanium as a standard material) in artificially drilled defect into right tibia. Animals were euthanized at four-week intervals. Bone samples with implants underwent microfocus CT scans and were histologically examined. Results WE43 alloys showed fragmentation of the material on the 16th week - statistically significant volume loss was found between weeks 12 and 16. Bone healing around the WE43 screws was of similar quality as around titanium screws, and no adverse effect was noticed. Conclusion The study showed good quality of bone healing around WE43 implants. From this point of view, the WE43 alloy meets the requirements of osteosynthetic material for maxillofacial skeleton.
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