Characteristics and application of S1-P1 nucleases in biotechnology and medicine
Language English Country England, Great Britain Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
PubMed
29248681
DOI
10.1016/j.biotechadv.2017.12.007
PII: S0734-9750(17)30159-3
Knihovny.cz E-resources
- Keywords
- Cancer treatment, Heteroduplex cleavage, Host-pathogen interaction, Leishmaniasis, Nuclease protection assay, Protozoan parasites, S1–P1 nuclease, Single-nucleotide mismatch, Structure-function relationship, TILLING,
- MeSH
- Biotechnology methods MeSH
- Molecular Targeted Therapy methods MeSH
- Single-Strand Specific DNA and RNA Endonucleases chemistry genetics metabolism pharmacology MeSH
- Fungal Proteins chemistry metabolism MeSH
- Host-Pathogen Interactions MeSH
- Humans MeSH
- DNA Mutational Analysis methods MeSH
- Nucleotidases metabolism MeSH
- Antineoplastic Agents pharmacology MeSH
- Substrate Specificity MeSH
- Structure-Activity Relationship MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- 3'-nucleotidase MeSH Browser
- Endonuclease S1, Aspergillus MeSH Browser
- Single-Strand Specific DNA and RNA Endonucleases MeSH
- Fungal Proteins MeSH
- Nuclease P1, Penicillium citrinum MeSH Browser
- Nucleotidases MeSH
- Antineoplastic Agents MeSH
3'-nucleases/nucleotidases of the S1-P1 family (EC 3.1.30.1) are single-strand-specific or non-specific zinc-dependent phosphoesterases present in plants, fungi, protozoan parasites, and in some bacteria. They participate in a wide variety of biological processes and their current biotechnological applications rely on their single-strand preference, nucleotide non-specificity, a broad range of catalytic conditions and high stability. We summarize the present and potential utilization of these enzymes in biotechnology and medicine in the context of their biochemical and structure-function properties. Explanation of unanswered questions for bacterial and trypanosomatid representatives could facilitate development of emerging applications in medicine.
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