Ipilimumab for the treatment of metastatic prostate cancer
Language English Country Great Britain, England Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
- Keywords
- Metastatic prostate cancer, PDL1 inhibitors, chemotherapy, circulating tumour cells, immunotherapy, ipilimumab, microRNA, vaccines,
- MeSH
- CTLA-4 Antigen immunology MeSH
- Immunotherapy MeSH
- Ipilimumab immunology pharmacokinetics therapeutic use MeSH
- Clinical Trials as Topic MeSH
- Combined Modality Therapy MeSH
- Humans MeSH
- Prostatic Neoplasms drug therapy pathology radiotherapy MeSH
- Cancer Vaccines immunology MeSH
- Check Tag
- Humans MeSH
- Male MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- CTLA-4 Antigen MeSH
- CTLA4 protein, human MeSH Browser
- Ipilimumab MeSH
- Cancer Vaccines MeSH
Immunotherapy with checkpoint inhibitors is beginning to be recognized as a valid weapon for the treatment of metastatic prostate cancer (PCa) when chemotherapy fails. Ipilimumab (ipi) is a fully humanized monoclonal antibody that blocks the activity of CTLA4. It also has a molecular weight of 148 kDa and is water-soluble at physiological pH. Ipi was first approved by the FDA for the treatment of malignant melanoma and is currently being studied in metastatic castration-resistant prostate cancer, with promising early results. Areas covered: The aim of this review is to collate the most significant preclinical and clinical studies available that look at ipi to propose new strategies for the future. Expert opinion: Additional studies are required to reduce toxicity and increase the activity of ipi in PCa. A possible strategy is to combine ipi with standard anti-cancer therapeutics such as vaccines, PDL1 inhibitors, antiandrogen drugs, and chemotherapy agents. Several initial results have suggested that combination strategies are useful to increase the activity in mCRPC, even if the toxicity of the treatment can increase. The activity of combined treatments is still not predictable, but considering the ongoing studies, we believe that they have good potential that will lead to the discovery of an optimal therapeutic strategy.
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