Ipilimumab for the treatment of metastatic prostate cancer
Jazyk angličtina Země Velká Británie, Anglie Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem, přehledy
- Klíčová slova
- Metastatic prostate cancer, PDL1 inhibitors, chemotherapy, circulating tumour cells, immunotherapy, ipilimumab, microRNA, vaccines,
- MeSH
- antigen CTLA-4 imunologie MeSH
- imunoterapie MeSH
- ipilimumab imunologie farmakokinetika terapeutické užití MeSH
- klinické zkoušky jako téma MeSH
- kombinovaná terapie MeSH
- lidé MeSH
- nádory prostaty farmakoterapie patologie radioterapie MeSH
- protinádorové vakcíny imunologie MeSH
- Check Tag
- lidé MeSH
- mužské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
- Názvy látek
- antigen CTLA-4 MeSH
- CTLA4 protein, human MeSH Prohlížeč
- ipilimumab MeSH
- protinádorové vakcíny MeSH
Immunotherapy with checkpoint inhibitors is beginning to be recognized as a valid weapon for the treatment of metastatic prostate cancer (PCa) when chemotherapy fails. Ipilimumab (ipi) is a fully humanized monoclonal antibody that blocks the activity of CTLA4. It also has a molecular weight of 148 kDa and is water-soluble at physiological pH. Ipi was first approved by the FDA for the treatment of malignant melanoma and is currently being studied in metastatic castration-resistant prostate cancer, with promising early results. Areas covered: The aim of this review is to collate the most significant preclinical and clinical studies available that look at ipi to propose new strategies for the future. Expert opinion: Additional studies are required to reduce toxicity and increase the activity of ipi in PCa. A possible strategy is to combine ipi with standard anti-cancer therapeutics such as vaccines, PDL1 inhibitors, antiandrogen drugs, and chemotherapy agents. Several initial results have suggested that combination strategies are useful to increase the activity in mCRPC, even if the toxicity of the treatment can increase. The activity of combined treatments is still not predictable, but considering the ongoing studies, we believe that they have good potential that will lead to the discovery of an optimal therapeutic strategy.
Citace poskytuje Crossref.org
