Repolarization in perfused myocardium predicts reperfusion ventricular tachyarrhythmias
Language English Country United States Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
29274899
DOI
10.1016/j.jelectrocard.2017.12.003
PII: S0022-0736(17)30449-1
Knihovny.cz E-resources
- Keywords
- Arrhythmias, ECG, Ischemia-reperfusion, Repolarization, Simulation,
- MeSH
- Electrocardiography * MeSH
- Ventricular Fibrillation physiopathology MeSH
- Cats MeSH
- Tachycardia, Ventricular physiopathology MeSH
- Disease Models, Animal MeSH
- Reperfusion Injury physiopathology MeSH
- Animals MeSH
- Check Tag
- Cats MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
BACKGROUND: Aim of the study was to find out which myocardial repolarization parameters predict reperfusion ventricular tachycardia and fibrillation (VT/VF) and determine how these parameters express in ECG. METHODS: Coronary occlusion and reperfusion (30/30min) was induced in 24 cats. Local activation and end of repolarization times (RT) were measured in 88 intramyocardial leads. Computer simulations of precordial electrograms were performed. RESULTS: Reperfusion VT/VF developed in 10 animals. Arrhythmia-susceptible animals had longer RTs in perfused areas [183(177;202) vs 154(140;170) ms in susceptible and resistant animals, respectively, P<0.05]. In logistic regression analysis, VT/VFs were associated with prolonged RTs in the perfused area (OR 1.068; 95% CI 1.012-1.128; P=0.017). Simulations demonstrated that prolonged repolarization in the perfused/border zone caused precordial terminal T-wave inversion. CONCLUSIONS: The reperfusion VT/VFs were independently predicted by the longer RT in the perfused zone, which was reflected in the terminal negative phase of the electrocardiographic T-wave.
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