The Role of Inflammation in Epicardial Adipose Tissue in Heart Diseases
Language English Country United Arab Emirates Media print
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
PubMed
29318960
DOI
10.2174/1381612824666180110102125
PII: CPD-EPUB-87799
Knihovny.cz E-resources
- Keywords
- Epicardial adipose tissue, adipokines, cardiovascular risk, cytokines, diabetes mellitus, inflammation, obesity.,
- MeSH
- Humans MeSH
- Heart Diseases metabolism pathology MeSH
- Pericardium metabolism pathology MeSH
- Adipose Tissue metabolism pathology MeSH
- Inflammation metabolism pathology MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
Epicardial adipose tissue is not only a specific adipose tissue depot but also an active endocrine organ producing numerous substances with an important role in the development of obesity-related heart diseases. It is located between myocardium and visceral pericardium and consists predominantly of adipocytes, immunocompetent cells, ganglia and interconnecting nerve branches. Several studies documented a positive correlation between pericardial and epicardial fat and left ventricular hypertrophy and septal thickening, leading to diastolic dysfunction, electrocardiographic abnormalities and facilitating cardiac failure. The cellular cross-talks between epicardial fat and myocardium may include both the vasocrine and the paracrine mechanisms. Adipokines secreted from epicardial adipose tissue, vascular and stromal cells diffuse into interstitial fluid crossing the adventitia, media and intima and modulate cardiac function and cardiomyocyte phenotype and survival. In this article, we review the significance of epicardial adipose tissue and its association with cardiovascular diseases, cellular interactions between epicardial fat and myocardium, secretions of adipokines and inflammatory mediators and a potential of epicardial fat as a therapeutic target for the prevention of obesity-related heart diseases.
1st Faculty of Medicine Charles University Prague Czech Republic
Diabetes Centre Institute for Clinical and Experimental Medicine Prague Czech Republic
References provided by Crossref.org
Osteopontin: The Molecular Bridge between Fat and Cardiac-Renal Disorders
