Endothelial cell-derived microvesicles: potential mediators and biomarkers of pathologic processes
Language English Country England, Great Britain Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
PubMed
29327597
DOI
10.2217/bmm-2017-0182
Knihovny.cz E-resources
- Keywords
- biomarkers, ectosomes, endothelial microvesicles, extracellular vesicles, inflammation, microparticles,
- MeSH
- Apoptosis MeSH
- Biomarkers metabolism MeSH
- Endothelial Cells cytology metabolism MeSH
- Exosomes metabolism MeSH
- Extracellular Vesicles metabolism MeSH
- Humans MeSH
- Cell-Derived Microparticles metabolism MeSH
- Neovascularization, Pathologic MeSH
- Thrombosis pathology MeSH
- Inflammation pathology MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- Biomarkers MeSH
This review focuses on the formation, composition and function of endothelial microvesicles (MV), often called microparticles (MP). MV release is a controlled event and is considered a hallmark of cellular activation or alteration. MV may affect the function of target cells through surface interaction and receptor activation, cellular fusion and the delivery of intravesicular cargo. Endothelial MV are released as a consequence of endothelial activation during inflammation and have been described to affect hemostasis, various aspects of inflammatory reaction, vessel formation, apoptosis and cell survival, endothelial cell differentiation and function. Recent data suggest the potential use of MV in diagnostics, assessment of severity and prediction of outcomes in inflammatory diseases and their utilization as targets, mediators and vectors in therapy.
References provided by Crossref.org
Endothelial Microvesicles and Soluble Markers of Endothelial Injury in Critically Ill Newborns
