18 F]Fluorodeoxyglucose PET/CT and prediction of histopathological response to neoadjuvant chemotherapy for adenocarcinoma of the oesophagus and oesophagogastric junction
Language English Country England, Great Britain Media print-electronic
Document type Clinical Trial, Journal Article, Multicenter Study
PubMed
29417984
DOI
10.1002/bjs.10712
Knihovny.cz E-resources
- MeSH
- Adenocarcinoma diagnostic imaging drug therapy pathology surgery MeSH
- Chemotherapy, Adjuvant MeSH
- Adult MeSH
- Fluorodeoxyglucose F18 * MeSH
- Esophagogastric Junction diagnostic imaging pathology MeSH
- Middle Aged MeSH
- Humans MeSH
- Esophageal Neoplasms diagnostic imaging drug therapy pathology surgery MeSH
- Neoadjuvant Therapy MeSH
- Positron Emission Tomography Computed Tomography * MeSH
- Prospective Studies MeSH
- Antineoplastic Agents therapeutic use MeSH
- Antineoplastic Combined Chemotherapy Protocols therapeutic use MeSH
- Radiopharmaceuticals * MeSH
- ROC Curve MeSH
- Aged MeSH
- Treatment Outcome MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Clinical Trial MeSH
- Multicenter Study MeSH
- Names of Substances
- Fluorodeoxyglucose F18 * MeSH
- Antineoplastic Agents MeSH
- Radiopharmaceuticals * MeSH
BACKGROUND: The aim of this prospective study was to assess whether [18 F]fluorodeoxyglucose PET can be used to predict histopathological response early in the course of neoadjuvant chemotherapy in patients with adenocarcinoma of the oesophagus and oesophagogastric junction. METHODS: Following the PET response criteria in solid tumours (PERCIST 1.0) as a standardized method for semiquantitative assessment of metabolic response, FDG-PET/CT was performed before (PET1) and after (PET2) initiation of the first cycle of chemotherapy. The relative changes in the peak standardized uptake value (ΔSUL) and total lesion glycolysis (ΔTLG) between PET1 and PET2 were correlated with histopathological response, defined as less than 50 per cent viable tumour cells in the resection specimen. A receiver operating characteristic (ROC) curve analysis was used to identify the optimal cut-off value with the highest accuracy of histopathological response prediction. RESULTS: PET2 was performed a median of 16 (range 12-22) days after the start of chemotherapy. Some 27 of 90 patients who underwent surgery had a histopathological response. There was no association between the median ΔSUL or median ΔTLG and the histopathological response. A post hoc analysis in 47 patients with PET2 performed 16 days or less after the start of chemotherapy showed that ΔTLG, but not ΔSUL, was associated with the histopathological response (P = 0·009). The optimal cut-off value of ΔTLG was 66 per cent or more. CONCLUSION: FDG-PET/CT after the first cycle of chemotherapy does not predict histopathological response in patients with adenocarcinoma of the oesophagus and oesophagogastric junction.
References provided by Crossref.org
