Prognostic significance of 1p36 locus deletion in adenoid cystic carcinoma of the salivary glands
Jazyk angličtina Země Německo Médium print-electronic
Typ dokumentu časopisecké články
Grantová podpora
SVV-2017-260 391
Ministerstvo Školství, Mládeže a Tělovýchovy
PubMed
29619555
DOI
10.1007/s00428-018-2349-6
PII: 10.1007/s00428-018-2349-6
Knihovny.cz E-zdroje
- Klíčová slova
- 1p36 locus deletion, Adenoid cystic carcinoma, MYB-NFIB, Prognosis, Salivary gland,
- MeSH
- adenoidně cystický karcinom genetika mortalita sekundární terapie MeSH
- časové faktory MeSH
- chromozomální delece * MeSH
- dospělí MeSH
- fenotyp MeSH
- fúze genů MeSH
- fúzní onkogenní proteiny genetika MeSH
- genetická predispozice k nemoci MeSH
- hybridizace in situ fluorescenční MeSH
- imunohistochemie MeSH
- Kaplanův-Meierův odhad MeSH
- lidé středního věku MeSH
- lidé MeSH
- lidské chromozomy, pár 1 * MeSH
- lokální recidiva nádoru MeSH
- mladiství MeSH
- mladý dospělý MeSH
- nádorové biomarkery genetika MeSH
- nádory slinných žláz genetika mortalita patologie terapie MeSH
- přežití po terapii bez příznaků nemoci MeSH
- progrese nemoci MeSH
- proporcionální rizikové modely MeSH
- protoonkogenní proteiny genetika MeSH
- rizikové faktory MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- staging nádorů MeSH
- stupeň nádoru MeSH
- trans-aktivátory genetika MeSH
- transkripční faktory NFI genetika MeSH
- výsledek terapie MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- fúzní onkogenní proteiny MeSH
- MYB-NFIB fusion protein, human MeSH Prohlížeč
- MYBL1 protein, human MeSH Prohlížeč
- nádorové biomarkery MeSH
- NFIB protein, human MeSH Prohlížeč
- protoonkogenní proteiny MeSH
- trans-aktivátory MeSH
- transkripční faktory NFI MeSH
Adenoid cystic carcinoma (AdCC) of the salivary glands is characterized by MYB-NFIB or MYBL1-NFIB fusion, prolonged but relentlessly progressive clinical course with frequent recurrences, and development of distant metastasis resulting in high long-term mortality. Currently, no effective therapy is available for patients with advanced non-resectable and/or metastatic disease. Complicating the clinical management of this patient group is the lack of prognostic markers. The purpose of this study is to investigate the prognostic value of 1p36 loss in patients with AdCC. The presence of 1p36 deletion and gene fusions involving the MYB, NFIB, and MYBL1 genes in a cohort of 93 salivary gland AdCCs was studied using fluorescence in situ hybridization. These results were statistically correlated with clinical data and outcome. Deletion of 1p36 in AdCC was identified in 13 of 85 analyzable cases (15.29%). MYB-NFIB fusion was detected in 57/85 (67.1%), MYBL1-NFIB fusion in 12/85 (14.1%), MYB-X fusion in 4/85 (4.7%), MYBL1-X in 4/85 (4.7%), and NFIB-X in 2/85 (2.4%) of AdCC cases. None of the 1p36-deleted samples showed MYBL1 rearrangement. Statistical analysis demonstrated a significant correlation between 1p36 deletion and advanced tumor stage and solid histology (p = 0.0061 and 0.0007, respectively). Kaplan-Meier survival curves showed statistically significant correlations between 1p36 deletion and decreased overall survival, disease-specific survival, recurrence-free interval, and recurrence-free survival, all of which were maintained in multivariate analysis. We demonstrate that 1p36 deletion can serve as an indicator of unfavorable outcome of patients with salivary gland AdCC.
Department of Oral Pathology Faculty of Dentistry University of São Paulo São Paulo Brazil
Department of Otorhinolaryngology and Maxillofacial Surgery Zealand University Hospital Køge Denmark
Department of Pathology Faculty of Medicine in Plzen Charles University Plzen Czech Republic
Department of Pathology Rigshospitalet Copenhagen University Hospital Copenhagen Denmark
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