Microevolution and independent incursions as main forces shaping H5 Hemagglutinin diversity during a H5N8/H5N5 highly pathogenic avian influenza outbreak in Czech Republic in 2017
Jazyk angličtina Země Rakousko Médium print-electronic
Typ dokumentu časopisecké články
PubMed
29623433
DOI
10.1007/s00705-018-3833-7
PII: 10.1007/s00705-018-3833-7
Knihovny.cz E-zdroje
- MeSH
- epidemický výskyt choroby MeSH
- fylogeneze MeSH
- genetická variace MeSH
- hemaglutininové glykoproteiny viru chřipky genetika MeSH
- molekulární evoluce * MeSH
- ptačí chřipka u ptáků epidemiologie virologie MeSH
- ptáci klasifikace virologie MeSH
- virulence MeSH
- virus chřipky A, podtyp H5N8 klasifikace genetika izolace a purifikace patogenita MeSH
- virus chřipky A klasifikace genetika izolace a purifikace patogenita MeSH
- zvířata MeSH
- Check Tag
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Geografické názvy
- Česká republika epidemiologie MeSH
- Názvy látek
- hemagglutinin, avian influenza A virus MeSH Prohlížeč
- hemaglutininové glykoproteiny viru chřipky MeSH
Here, we present a comprehensive analysis of the H5N8/H5N5 highly pathogenic avian influenza (HPAI) virus strains detected in the Czech Republic during an outbreak in 2017. Network analysis of the H5 Hemagglutinin (HA) from 99% of the outbreak localities suggested that the diversity of the Czech H5N8/H5N5 viruses was influenced by two basic forces: local microevolution and independent incursions. The geographical occurrence of the central node H5 HA sequences revealed three eco-regions, which apparently played an important role in the origin and further spread of the local H5N8/HPAI variants across the country. A plausible explanation for the observed pattern of diversity is also provided.
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