Screening of medicinal plants traditionally used in Peruvian Amazon for in vitro antioxidant and anticancer potential
Jazyk angličtina Země Anglie, Velká Británie Médium print-electronic
Typ dokumentu časopisecké články, audiovizuální média
- Klíčová slova
- Alkaloids, medicinal plants, oxidative stress, phenolic compounds, plant extracts, tumour,
- MeSH
- alkaloidy analýza MeSH
- Amaranthaceae chemie MeSH
- antioxidancia chemie farmakologie MeSH
- Caco-2 buňky MeSH
- fenoly analýza MeSH
- fytogenní protinádorové látky farmakologie MeSH
- léčivé rostliny chemie MeSH
- lidé MeSH
- nádorové buněčné linie MeSH
- oxidační stres MeSH
- rostlinné extrakty chemie farmakologie MeSH
- tradiční lékařství MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- audiovizuální média MeSH
- časopisecké články MeSH
- Geografické názvy
- Peru MeSH
- Názvy látek
- alkaloidy MeSH
- antioxidancia MeSH
- fenoly MeSH
- fytogenní protinádorové látky MeSH
- rostlinné extrakty MeSH
Plants mentioned in this study have numerous records in traditional Peruvian medicine being used in treatment of cancer and other diseases likely to be associated with oxidative stress. Amongst the eight plant species tested, only Dysphania ambrosioides exhibited combinatory antioxidant and anti-proliferative effect on a broad spectrum of cancer cells (DPPH and ORAC values = 80.6 and 687.3 μg TE/mg extract, respectively; IC50 against Caco-2, HT-29 and Hep-G2 = 129.2, 69.9 and 130.6, respectively). Alkaloids and phenolic compounds might significantly contribute to anticancer/antioxidant activity of this plant. The results justify the traditional medicinal use of this plant. Our findings further suggest that D. ambrosioides might serve as a prospective material for further development of novel plant-based antioxidant and/or anti-proliferative agents. Detailed analysis of chemical composition together with toxicology assessments and in vivo antioxidant/anti-proliferative activity of this plant should be carried out in order to verify its potential practical use.
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