Screening of medicinal plants traditionally used in Peruvian Amazon for in vitro antioxidant and anticancer potential
Language English Country England, Great Britain Media print-electronic
Document type Journal Article, Video-Audio Media
- Keywords
- Alkaloids, medicinal plants, oxidative stress, phenolic compounds, plant extracts, tumour,
- MeSH
- Alkaloids analysis MeSH
- Amaranthaceae chemistry MeSH
- Antioxidants chemistry pharmacology MeSH
- Caco-2 Cells MeSH
- Phenols analysis MeSH
- Antineoplastic Agents, Phytogenic pharmacology MeSH
- Plants, Medicinal chemistry MeSH
- Humans MeSH
- Cell Line, Tumor MeSH
- Oxidative Stress MeSH
- Plant Extracts chemistry pharmacology MeSH
- Medicine, Traditional MeSH
- Check Tag
- Humans MeSH
- Publication type
- Video-Audio Media MeSH
- Journal Article MeSH
- Geographicals
- Peru MeSH
- Names of Substances
- Alkaloids MeSH
- Antioxidants MeSH
- Phenols MeSH
- Antineoplastic Agents, Phytogenic MeSH
- Plant Extracts MeSH
Plants mentioned in this study have numerous records in traditional Peruvian medicine being used in treatment of cancer and other diseases likely to be associated with oxidative stress. Amongst the eight plant species tested, only Dysphania ambrosioides exhibited combinatory antioxidant and anti-proliferative effect on a broad spectrum of cancer cells (DPPH and ORAC values = 80.6 and 687.3 μg TE/mg extract, respectively; IC50 against Caco-2, HT-29 and Hep-G2 = 129.2, 69.9 and 130.6, respectively). Alkaloids and phenolic compounds might significantly contribute to anticancer/antioxidant activity of this plant. The results justify the traditional medicinal use of this plant. Our findings further suggest that D. ambrosioides might serve as a prospective material for further development of novel plant-based antioxidant and/or anti-proliferative agents. Detailed analysis of chemical composition together with toxicology assessments and in vivo antioxidant/anti-proliferative activity of this plant should be carried out in order to verify its potential practical use.
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