Allergen immunotherapy in people, dogs, cats and horses - differences, similarities and research needs
Language English Country Denmark Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
Grant support
EAACI - International
F4606-B28
Austrian Science Fund FWF Grants - International
310030-160196/1
Swiss National Science Foundation - Switzerland
PubMed
29675865
DOI
10.1111/all.13464
Knihovny.cz E-resources
- Keywords
- and tolerance induction, animal models, asthma, atopic dermatitis, clinical immunology,
- MeSH
- Adjuvants, Immunologic MeSH
- Allergens immunology MeSH
- Hypersensitivity classification MeSH
- Dermatitis, Atopic immunology MeSH
- Desensitization, Immunologic methods veterinary MeSH
- Arthropod Venoms immunology MeSH
- Cats MeSH
- Horses MeSH
- Humans MeSH
- Models, Animal MeSH
- Dogs MeSH
- Animals MeSH
- Check Tag
- Cats MeSH
- Humans MeSH
- Dogs MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- Adjuvants, Immunologic MeSH
- Allergens MeSH
- Arthropod Venoms MeSH
In human patients with seasonal allergic rhinoconjunctivitis sensitized to grass pollen, the first successful allergen immunotherapy (AIT) was reported in 1911. Today, immunotherapy is an accepted treatment for allergic asthma, allergic rhinitis and hypersensitivities to insect venom. AIT is also used for atopic dermatitis and recently for food allergy. Subcutaneous, epicutaneous, intralymphatic, oral and sublingual protocols of AIT exist. In animals, most data are available in dogs where subcutaneous AIT is an accepted treatment for atopic dermatitis. Initiating a regulatory response and a production of "blocking" IgG antibodies with AIT are similar mechanisms in human beings and dogs with allergic diseases. Although subcutaneous immunotherapy is used for atopic dermatitis in cats, data for its efficacy are sparse. There is some evidence for successful treatment of feline asthma with AIT. In horses, most studies evaluate the effect of AIT on insect hypersensitivity with conflicting results although promising pilot studies have demonstrated the prophylaxis of insect hypersensitivity with recombinant antigens of biting midges (Culicoides spp.). Optimizing AIT using allergoids, peptide immunotherapy, recombinant allergens and new adjuvants with the different administration types of allergen extracts will further improve compliance and efficacy of this proven treatment modality.
Centre for Clinical Veterinary Medicine LMU Munich Munich Germany
Department of Clinical Research and Veterinary Public Health University of Bern Bern Switzerland
Faculty of Science Charles University Prague Czech Republic
Immunology and Microbiology Department Faculty of Veterinary Medicine Cairo University Giza Egypt
School of Veterinary Medicine University of Wisconsin Madison WI USA
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