Angiopoietin-like protein 3 and 4 in obesity, type 2 diabetes mellitus, and malnutrition: the effect of weight reduction and realimentation
Jazyk angličtina Země Anglie, Velká Británie Médium electronic
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
29695708
PubMed Central
PMC5916880
DOI
10.1038/s41387-018-0032-2
PII: 10.1038/s41387-018-0032-2
Knihovny.cz E-zdroje
- MeSH
- angiopoetinu podobné proteiny krev MeSH
- angiopoetinu podobný protein 3 MeSH
- angiopoetinu podobný protein 4 krev MeSH
- bariatrická chirurgie MeSH
- chirurgie trávicího traktu MeSH
- diabetes mellitus 2. typu krev MeSH
- hmotnostní úbytek fyziologie MeSH
- lidé středního věku MeSH
- lidé MeSH
- obezita krev chirurgie MeSH
- podvýživa krev MeSH
- syndrom krátkého střeva krev chirurgie MeSH
- výsledek terapie MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- angiopoetinu podobné proteiny MeSH
- angiopoetinu podobný protein 3 MeSH
- angiopoetinu podobný protein 4 MeSH
- ANGPTL3 protein, human MeSH Prohlížeč
- ANGPTL4 protein, human MeSH Prohlížeč
BACKGROUND: Angiopoietin-like proteins (ANGPTLs) 3 and 4 are circulating factors that participate in the regulation of lipid and glucose metabolism. SUBJECTS AND METHODS: We measured serum ANGPTL3 and 4 levels in 23 patients with obesity, 40 patients with obesity and type 2 diabetes mellitus (T2DM), 22 patients with anorexia nervosa (AN), 15 subjects undergoing 72-h fasting, and 12 patients with short bowel syndrome (SBS), and their changes after very-low-calorie diet (VLCD), bariatric surgery, partial realimentation, acute fasting, and parenteral nutrition in order to assess their possible role in metabolic regulations. RESULTS: Serum ANGPTL4 levels were higher in obese subjects without/with T2DM (94.50 ± 9.51 and 134.19 ± 7.69 vs. 50.34 ± 4.22 ng/ml, p < 0.001) and lower in subjects with AN relative to healthy control subjects (38.22 ± 4.48 vs. 65.80 ± 7.98 ng/ml, p = 0.002), while serum ANGPTL3 levels demonstrated inverse tendency. Nutritional status had no effect on ANGPTL3 and 4 mRNA expression in adipose tissue. Fasting decreased ANGPTL3 and increased ANGPTL4 levels, while VLCD reduced only ANGPTL3. Bariatric surgery and realimentation of AN or SBS patients had no effect on either ANGPTL. Multiple regression analysis identified BMI as an independent predictor of ANGPTL3; and BMI and HbA1c as independent predictors of ANGPTL4, respectively. CONCLUSIONS: Taken together, our data suggest that serum ANGPTL3 and 4 levels are influenced by nutritional status and fasting and could be involved in the metabolic disturbances present in obesity and AN.
Zobrazit více v PubMed
Fagiani E, Christofori G. Angiopoietins in angiogenesis. Cancer Lett. 2013;328:18–26. doi: 10.1016/j.canlet.2012.08.018. PubMed DOI
George J. Angiopoietin-like proteins: another player in the metabolic field. J. Hepatol. 2006;44:832–834. doi: 10.1016/j.jhep.2006.01.010. PubMed DOI
Oike Y, Yasunaga K, Suda T. Angiopoietin-related/angiopoietin-like proteins regulate angiogenesis. Int. J. Hematol. 2004;80:21–28. doi: 10.1532/IJH97.04034. PubMed DOI
Xu L, et al. Angiopoietin-like 4: a double-edged sword in Atherosclerosis and ischemic stroke? Exp. Neurol. 2015;272:61–66. doi: 10.1016/j.expneurol.2015.05.020. PubMed DOI PMC
Zhang CC, et al. Angiopoietin-like proteins stimulate ex vivo expansion of hematopoietic stem cells. Nat. Med. 2006;12:240–245. doi: 10.1038/nm1342. PubMed DOI PMC
Schumacher A, et al. Angptl4 is upregulated under inflammatory conditions in the bone marrow of mice, expands myeloid progenitors, and accelerates reconstitution of platelets after myelosuppressive therapy. J. Hematol. Oncol. 2015;8:64. doi: 10.1186/s13045-015-0152-2. PubMed DOI PMC
Nakayama T, et al. Expression of angiopoietin-like 4 in human gastric cancer: ANGPTL4 promotes venous invasion. Oncol. Rep. 2010;24:599–606. doi: 10.3892/or_00000897. PubMed DOI
Sun Y, Long J, Zhou Y. Angiopoietin-like 4 promotes melanoma cell invasion and survival through aldolase A. Oncol. Lett. 2014;8:211–217. doi: 10.3892/ol.2014.2071. PubMed DOI PMC
Mattijssen F, Kersten S. Regulation of triglyceride metabolism by Angiopoietin-like proteins. Biochim. Biophys. Acta. 2012;1821:782–789. doi: 10.1016/j.bbalip.2011.10.010. PubMed DOI
Sukonina V, Lookene A, Olivecrona T, Olivecrona G. Angiopoietin-like protein 4 converts lipoprotein lipase to inactive monomers and modulates lipase activity in adipose tissue. Proc. Natl Acad. Sci. USA. 2006;103:17450–17455. doi: 10.1073/pnas.0604026103. PubMed DOI PMC
Ge H, et al. Differential regulation and properties of angiopoietin-like proteins 3 and 4. J. Lipid Res. 2005;46:1484–1490. doi: 10.1194/jlr.M500005-JLR200. PubMed DOI
Mehta N, et al. Differential association of plasma angiopoietin-like proteins 3 and 4 with lipid and metabolic traits. Arterioscler. Thromb. Vasc. Biol. 2014;34:1057–1063. doi: 10.1161/ATVBAHA.113.302802. PubMed DOI PMC
Koster A, et al. Transgenic angiopoietin-like (angptl)4 overexpression and targeted disruption of angptl4 and angptl3: regulation of triglyceride metabolism. Endocrinology. 2005;146:4943–4950. doi: 10.1210/en.2005-0476. PubMed DOI
Shan L, et al. The angiopoietin-like proteins ANGPTL3 and ANGPTL4 inhibit lipoprotein lipase activity through distinct mechanisms. J. Biol. Chem. 2009;284:1419–1424. doi: 10.1074/jbc.M808477200. PubMed DOI PMC
Kaplan R, et al. Regulation of the angiopoietin-like protein 3 gene by LXR. J. Lipid Res. 2003;44:136–143. doi: 10.1194/jlr.M200367-JLR200. PubMed DOI
Steffensen KR, Gustafsson JA. Putative metabolic effects of the liver X receptor (LXR) Diabetes. 2004;53:S36–S42. doi: 10.2337/diabetes.53.2007.S36. PubMed DOI
Dijk W, Kersten S. Regulation of lipoprotein lipase by Angptl4. Trends Endocrinol. Metab. 2014;25:146–155. doi: 10.1016/j.tem.2013.12.005. PubMed DOI
Kavalkova P, et al. Preadipocyte factor-1 concentrations in patients with anorexia nervosa: the influence of partial realimentation. Physiol. Res. 2012;61:153–159. PubMed
Zhang R. The ANGPTL3-4-8 model, a molecular mechanism for triglyceride trafficking. Open Biol. 2016;6:150272. doi: 10.1098/rsob.150272. PubMed DOI PMC
Kersten S, et al. Caloric restriction and exercise increase plasma ANGPTL4 levels in humans via elevated free fatty acids. Arterioscler. Thromb. Vasc. Biol. 2009;29:969–974. doi: 10.1161/ATVBAHA.108.182147. PubMed DOI
Dutton S, Trayhurn P. Regulation of angiopoietin-like protein 4/fasting-induced adipose factor (Angptl4/FIAF) expression in mouse white adipose tissue and 3T3-L1 adipocytes. Br. J. Nutr. 2008;100:18–26. doi: 10.1017/S0007114507882961. PubMed DOI
Minicocci I, et al. Effects of angiopoietin-like protein 3 deficiency on postprandial lipid and lipoprotein metabolism. J. Lipid Res. 2016;57:1097–1107. doi: 10.1194/jlr.P066183. PubMed DOI PMC
Tjeerdema N, et al. Inflammation increases plasma angiopoietin-like protein 4 in patients with the metabolic syndrome and type 2 diabetes. BMJ Open Diabetes Res. Care. 2014;2:e000034. doi: 10.1136/bmjdrc-2014-000034. PubMed DOI PMC
Abu-Farha M, et al. Increased ANGPTL3, 4 and ANGPTL8/betatrophin expression levels in obesity and T2D. Lipids Health Dis. 2016;15:181. doi: 10.1186/s12944-016-0337-x. PubMed DOI PMC
Jonker JT, et al. Dietary modulation of plasma angiopoietin-like protein 4 concentrations in healthy volunteers and in patients with type 2 diabetes. Am. J. Clin. Nutr. 2013;97:255–260. doi: 10.3945/ajcn.112.043687. PubMed DOI
Xu A, et al. Angiopoietin-like protein 4 decreases blood glucose and improves glucose tolerance but induces hyperlipidemia and hepatic steatosis in mice. Proc. Natl Acad. Sci. USA. 2005;102:6086–6091. doi: 10.1073/pnas.0408452102. PubMed DOI PMC
Wang Y, et al. Angiopoietin-like protein 4 improves glucose tolerance and insulin resistance but induces liver steatosis in high-fat-diet mice. Mol. Med. Rep. 2016;14:3293–3300. doi: 10.3892/mmr.2016.5637. PubMed DOI
Chung HS, et al. Circulating angiopoietin-like protein 8 (ANGPTL8) and ANGPTL3 concentrations in relation to anthropometric and metabolic profiles in Korean children: a prospective cohort study. Cardiovasc. Diabetol. 2016;15:1. doi: 10.1186/s12933-015-0324-y. PubMed DOI PMC
Zhao D, et al. Different relationship between ANGPTL3 and HDL components in female non-diabetic subjects and type-2 diabetic patients. Cardiovasc. Diabetol. 2016;15:132. doi: 10.1186/s12933-016-0450-1. PubMed DOI PMC
Nidhina Haridas PA, et al. Regulation of angiopoietin-like proteins (ANGPTLs) 3 and 8 by insulin. J. Clin. Endocrinol. Metab. 2015;100:E1299–E1307. doi: 10.1210/jc.2015-1254. PubMed DOI
Tikka A, et al. Silencing of ANGPTL 3 (angiopoietin-like protein 3) in human hepatocytes results in decreased expression of gluconeogenic genes and reduced triacylglycerol-rich VLDL secretion upon insulin stimulation. Biosci. Rep. 2014;34:e00160. doi: 10.1042/BSR20140115. PubMed DOI PMC
Gusarova V, et al. ANGPTL3 blockade with a human monoclonal antibody reduces plasma lipids in dyslipidemic mice and monkeys. J. Lipid Res. 2015;56:1308–1317. doi: 10.1194/jlr.M054890. PubMed DOI PMC
Dewey FE, et al. Genetic and pharmacologic inactivation of ANGPTL3 and cardiovascular disease. N. Engl. J. Med. 2017;377:211–221. doi: 10.1056/NEJMoa1612790. PubMed DOI PMC
Cullberg KB, et al. Effect of weight loss and exercise on angiogenic factors in the circulation and in adipose tissue in obese subjects. Obesity (Silver Spring) 2013;21:454–460. doi: 10.1002/oby.20060. PubMed DOI
Mandard S, et al. The direct peroxisome proliferator-activated receptor target fasting-induced adipose factor (FIAF/PGAR/ANGPTL4) is present in blood plasma as a truncated protein that is increased by fenofibrate treatment. J. Biol. Chem. 2004;279:34411–34420. doi: 10.1074/jbc.M403058200. PubMed DOI
Romeo S, et al. Rare loss-of-function mutations in ANGPTL family members contribute to plasma triglyceride levels in humans. J. Clin. Invest. 2009;119:70–79. PubMed PMC
Nidhina Haridas PA, et al. Regulation of angiopoietin-like proteins (ANGPTLs) 3 and 8 by insulin. J. Clin. Endocrinol. Metab. 2015;100:E1299–E1307. doi: 10.1210/jc.2015-1254. PubMed DOI
Cardio- and Neurometabolic Adipobiology: Consequences and Implications for Therapy