M1/M2 macrophage polarization in human obese adipose tissue
Jazyk angličtina Země Česko Médium print-electronic
Typ dokumentu časopisecké články, přehledy
PubMed
29765169
DOI
10.5507/bp.2018.015
Knihovny.cz E-zdroje
- Klíčová slova
- M1/M2 macrophages, adipose tissue, chemokines, inflammation, obesity,
- MeSH
- chemokin CCL2 metabolismus MeSH
- fenotyp MeSH
- hypoxie metabolismus patologie MeSH
- interleukin-6 metabolismus MeSH
- inzulinová rezistence fyziologie MeSH
- lidé MeSH
- makrofágy patologie MeSH
- obezita metabolismus patologie MeSH
- TNF-alfa metabolismus MeSH
- tuková tkáň patologie MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
- Názvy látek
- CCL2 protein, human MeSH Prohlížeč
- chemokin CCL2 MeSH
- interleukin-6 MeSH
- TNF-alfa MeSH
Obesity and insulin resistance are closely associated with chronic inflammation in adipose tissue, where macrophages play an important role. Adipose tissue macrophages can be divided into two main phenotypes: the classical M1 macrophages and alternatively activated macrophages M2. M1 macrophages produce pro-inflammatory cytokines (TNF-α, interleukin IL-6 and MCP-1) and thus contribute to the development of insulin resistance. On the other hand, M2 macrophages, anti-inflammatory, are involved in the maintenance of tissue homeostasis and are typical in the adipose tissue of slender individuals. Macrophages can also play a role in the pathogenesis of other serious illnesses such as cardiovascular diseases or cancer. This article reviews the latest data on macrophage polarization in adipose tissue.
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