The course of experimental giardiasis in Mongolian gerbil
Language English Country Germany Media print-electronic
Document type Journal Article
Grant support
P505/11/1163
Grantová Agentura České Republiky
PřF_04_27.10.2006
Scholarship program to support creative activity - research collaboration
PubMed
29797082
DOI
10.1007/s00436-018-5932-5
PII: 10.1007/s00436-018-5932-5
Knihovny.cz E-resources
- Keywords
- Gerbil model, Giardia intestinalis, Giardial intestinal distribution, Giardiasis,
- MeSH
- Duodenum parasitology pathology MeSH
- Feces parasitology MeSH
- Gerbillinae * parasitology MeSH
- Giardia lamblia growth & development physiology MeSH
- Giardiasis parasitology pathology MeSH
- Humans MeSH
- Microscopy, Electron, Scanning MeSH
- Disease Models, Animal MeSH
- Trophozoites growth & development physiology MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Male MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
Fifteen Mongolian gerbils were inoculated with 10 × 106 viable trophozoites of Giardia intestinalis. Their faeces were examined daily by flotation method and the number of shed cysts was counted. Two animals (male and female) were euthanised at 4- to 5-day intervals (9, 14, 18 days post-infection (DPI)). The remaining nine gerbils were sacrificed and dissected at the end of the experiment (23 DPI). Their small intestinal tissues were processed for examination using histological sectioning and scanning electron microscopy and their complete blood count (CBC) was examined. The highest number of trophozoites at the total was observed in the duodenum in gerbils sacrificed on 14 DPI. Number of shed cysts was positively correlated with number of trophozoites rinsed from the intestine. Infected gerbils had lower body weight gain in comparison with control group and in three male gerbils; diarrhoea occurred during infection. Cyst shedding was negatively correlated with values of mean corpuscular haemoglobin concentration. Females showed another pattern in cyst shedding than males. This information needs to be taken into account while planning the experiments.
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