Effects of the adipokinetic hormone/red pigment-concentrating hormone (AKH/RPCH) family of peptides on MK-801-induced schizophrenia models
Jazyk angličtina Země Anglie, Velká Británie Médium print-electronic
Typ dokumentu časopisecké články
Grantová podpora
P304/12/G069
Grant Agency of the Czech Republic
P304/14/20613S
Grant Agency of the Czech Republic
LO1611
National Institute of Mental Health
Ministry of Education, Youth and Sports of the Czech Republic
PubMed
29863789
DOI
10.1111/fcp.12386
Knihovny.cz E-zdroje
- Klíčová slova
- MK-801, adipokinetic hormone, rat, schizophrenia,
- MeSH
- anxiolytika farmakologie MeSH
- dizocilpinmaleát farmakologie MeSH
- hmyzí hormony farmakologie MeSH
- krysa rodu Rattus MeSH
- kyselina pyrrolidonkarboxylová analogy a deriváty farmakologie MeSH
- modely nemocí na zvířatech MeSH
- neuropeptidy farmakologie MeSH
- neuroprotektivní látky MeSH
- oligopeptidy farmakologie MeSH
- paměť účinky léků MeSH
- peptidy farmakologie MeSH
- poruchy paměti chemicky indukované farmakoterapie MeSH
- potkani Long-Evans MeSH
- potkani Wistar MeSH
- schizofrenie chemicky indukované farmakoterapie MeSH
- zvířata MeSH
- Check Tag
- krysa rodu Rattus MeSH
- mužské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- adipokinetic hormone MeSH Prohlížeč
- anxiolytika MeSH
- dizocilpinmaleát MeSH
- hmyzí hormony MeSH
- hypertrehalosemic hormone MeSH Prohlížeč
- kyselina pyrrolidonkarboxylová MeSH
- neuropeptidy MeSH
- neuroprotektivní látky MeSH
- oligopeptidy MeSH
- peptidy MeSH
- red pigment-concentrating hormone MeSH Prohlížeč
The adipokinetic and red pigment-concentrating hormone (AKH/RPCH) family of peptides controls fat, carbohydrate, and protein metabolism in insects. In our previous study, we showed that AKH possesses antidepressant, anxiolytic, and analgesic effects, causes hyperlocomotion, and exerts neuroprotective effects and increased brain neurotrophic factors in mice. The aim of this study was to investigate the effects of Anax imperator AKH (Ani-AKH), Libellula auripennis AKH (Lia-AKH), and Phormia-Terra hypertrehalosemic hormone (Pht-HrTH) on MK-801-induced memory deterioration in the active allothetic place avoidance test (AAPA) and MK-801-induced sensorimotor gating deficit in the prepulse inhibition test (PPI). In the AAPA task, Long-Evans rats were treated with Ani-AKH (2 mg/kg), Lia-AKH (2 mg/kg), Pht-HrTH (2 mg/kg), MK-801 (0.15 mg/kg), and the combination of MK-801 with the hormones subchronically. In the prepulse inhibition test, Wistar albino rats were treated with Ani-AKH (1 mg/kg), Lia-AKH (1 mg/kg), Pht-HrTH (1 mg/kg), MK-801 (0.1 mg/kg), or the combination of MK-801 with hormones acutely before the test. In our study, Ani-AKH (2 mg/kg), Lia-AKH (2 mg/kg), and Pht-HrTH (2 mg/kg) reversed MK-801 (0.15 mg/kg)-induced cognitive memory impairment effects in the AAPA task. Lia-AKH (1 mg/kg) significantly potentiated the MK-801-induced PPI disruption, while Ani-AKH (1 mg/kg) partially potentiated the impairment caused by MK-801, and Pht-HrTH did not modify the effect of MK-801. In conclusion, AKH had no effect in sensorimotor gating deficits in the PPI test in schizophrenia model while AKH improved memory in the schizophrenia model of MK-801.
National Institute of Mental Health Topolova 748 Klecany 250 67 Czech Republic
Pharmacology Department Kocaeli University Medical Faculty Kocaeli 41380 Turkey
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