Effects of the adipokinetic hormone/red pigment-concentrating hormone (AKH/RPCH) family of peptides on MK-801-induced schizophrenia models
Language English Country England, Great Britain Media print-electronic
Document type Journal Article
Grant support
P304/12/G069
Grant Agency of the Czech Republic
P304/14/20613S
Grant Agency of the Czech Republic
LO1611
National Institute of Mental Health
Ministry of Education, Youth and Sports of the Czech Republic
PubMed
29863789
DOI
10.1111/fcp.12386
Knihovny.cz E-resources
- Keywords
- MK-801, adipokinetic hormone, rat, schizophrenia,
- MeSH
- Anti-Anxiety Agents pharmacology MeSH
- Dizocilpine Maleate pharmacology MeSH
- Insect Hormones pharmacology MeSH
- Rats MeSH
- Pyrrolidonecarboxylic Acid analogs & derivatives pharmacology MeSH
- Disease Models, Animal MeSH
- Neuropeptides pharmacology MeSH
- Neuroprotective Agents MeSH
- Oligopeptides pharmacology MeSH
- Memory drug effects MeSH
- Peptides pharmacology MeSH
- Memory Disorders chemically induced drug therapy MeSH
- Rats, Long-Evans MeSH
- Rats, Wistar MeSH
- Schizophrenia chemically induced drug therapy MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- adipokinetic hormone MeSH Browser
- Anti-Anxiety Agents MeSH
- Dizocilpine Maleate MeSH
- Insect Hormones MeSH
- hypertrehalosemic hormone MeSH Browser
- Pyrrolidonecarboxylic Acid MeSH
- Neuropeptides MeSH
- Neuroprotective Agents MeSH
- Oligopeptides MeSH
- Peptides MeSH
- red pigment-concentrating hormone MeSH Browser
The adipokinetic and red pigment-concentrating hormone (AKH/RPCH) family of peptides controls fat, carbohydrate, and protein metabolism in insects. In our previous study, we showed that AKH possesses antidepressant, anxiolytic, and analgesic effects, causes hyperlocomotion, and exerts neuroprotective effects and increased brain neurotrophic factors in mice. The aim of this study was to investigate the effects of Anax imperator AKH (Ani-AKH), Libellula auripennis AKH (Lia-AKH), and Phormia-Terra hypertrehalosemic hormone (Pht-HrTH) on MK-801-induced memory deterioration in the active allothetic place avoidance test (AAPA) and MK-801-induced sensorimotor gating deficit in the prepulse inhibition test (PPI). In the AAPA task, Long-Evans rats were treated with Ani-AKH (2 mg/kg), Lia-AKH (2 mg/kg), Pht-HrTH (2 mg/kg), MK-801 (0.15 mg/kg), and the combination of MK-801 with the hormones subchronically. In the prepulse inhibition test, Wistar albino rats were treated with Ani-AKH (1 mg/kg), Lia-AKH (1 mg/kg), Pht-HrTH (1 mg/kg), MK-801 (0.1 mg/kg), or the combination of MK-801 with hormones acutely before the test. In our study, Ani-AKH (2 mg/kg), Lia-AKH (2 mg/kg), and Pht-HrTH (2 mg/kg) reversed MK-801 (0.15 mg/kg)-induced cognitive memory impairment effects in the AAPA task. Lia-AKH (1 mg/kg) significantly potentiated the MK-801-induced PPI disruption, while Ani-AKH (1 mg/kg) partially potentiated the impairment caused by MK-801, and Pht-HrTH did not modify the effect of MK-801. In conclusion, AKH had no effect in sensorimotor gating deficits in the PPI test in schizophrenia model while AKH improved memory in the schizophrenia model of MK-801.
National Institute of Mental Health Topolova 748 Klecany 250 67 Czech Republic
Pharmacology Department Kocaeli University Medical Faculty Kocaeli 41380 Turkey
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