Theory of Mind Skills Are Related to Resting-State Frontolimbic Connectivity in Schizophrenia
Language English Country United States Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
- Keywords
- fMRI, resting-state functional connectivity, schizophrenia, seed voxel analysis, theory of mind,
- MeSH
- Frontal Lobe diagnostic imaging MeSH
- Adult MeSH
- Emotions MeSH
- Cognition Disorders etiology MeSH
- Oxygen blood MeSH
- Humans MeSH
- Limbic System diagnostic imaging MeSH
- Magnetic Resonance Imaging MeSH
- Brain Mapping * MeSH
- Neural Pathways diagnostic imaging physiopathology MeSH
- Neuropsychological Tests MeSH
- Rest MeSH
- Image Processing, Computer-Assisted MeSH
- Recognition, Psychology MeSH
- Schizophrenia complications diagnostic imaging MeSH
- Social Behavior MeSH
- Theory of Mind physiology MeSH
- Self Report MeSH
- Check Tag
- Adult MeSH
- Humans MeSH
- Male MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Oxygen MeSH
Patients with schizophrenia (SCH) often demonstrate impairment in social-cognitive functions as well as disturbances in large-scale network connectivity. The ventromedial prefrontal cortex (vmPFC) is a core region of the default mode network, with projections to limbic structures. It plays an important role in social and emotional decision-making. We investigated whether resting-state functional connectivity (FC) relates to the cognitive and affective domains of theory of mind (ToM). Twenty-three SCH patients and 19 healthy controls (HCs) underwent resting-state functional magnetic resonance imaging scanning. vmPFC seed connectivity was correlated with behavioral measures assessing ToM domains. SCH performed less well than HCs in both ToM task domains. An analysis of the resting-state FC revealed that SCH had reduced connectivity from the vmPFC to the subcallosal cortex, right amygdala, and right hippocampus as a function of behavioral scores in both ToM domains. Within-group analyses indicated that in HCs, the performance in ToM was positively associated with frontoamygdalar resting-state connectivity, whereas in SCH, the performance in ToM was negatively associated with the frontosubcallosal connectivity. Differences in the pattern of the resting-state frontolimbic connectivity and its associations with performance in ToM tasks between the two study groups might represent a different setup for processing social information in patients with SCH.
Centre for Research on Aging Donald Berman Maimonides Geriatric Centre Montreal Canada
Department of Neurology Medical School University of Minnesota Minneapolis Minnesota
Functional Neuroimaging Unit Research Centre of the Montreal Geriatric Institute Montreal Canada
Psychiatry Department University of Montreal Montreal Canada
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