Neurotransplantation therapy
Language English Country Netherlands Media print
Document type Journal Article, Review
PubMed
29891073
DOI
10.1016/b978-0-444-64189-2.00025-1
PII: B978-0-444-64189-2.00025-1
Knihovny.cz E-resources
- Keywords
- cerebellar ataxias, cerebellar compensation, cerebellar reserve, cerebellum, neurotransplantation, stem cells, treatment,
- MeSH
- Cerebellar Ataxia surgery MeSH
- Humans MeSH
- Disease Models, Animal MeSH
- Brain Tissue Transplantation methods MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Review MeSH
Neurotransplantation may be a promising approach for therapy of cerebellar diseases characterized by a substantial loss of neurons. Neurotransplantation could rescue neurons from degeneration and maintain cerebellar reserve, facilitate cerebellar compensation, or help reconstruct damaged neural circuits by cell substitution. These mechanisms of action can be of varying importance according to the type of cerebellar disease. Neurotransplantation therapy in cerebellar ataxias is still at the stage of experimental studies. There is currently little knowledge regarding cerebellar patients. Nevertheless, data provided by experiments in animal models of cerebellar degeneration and both clinical studies and experiences in patients with other neurologic diseases enable us to suggest basic principles, expectations, limitations, and future directions of neurotransplantation therapy for cerebellar diseases.
References provided by Crossref.org
Lurcher Mouse as a Model of Cerebellar Syndromes
