Gastric fluid used to assess changes during the latency period in preterm prelabor rupture of membranes
Language English Country United States Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
29892034
DOI
10.1038/s41390-018-0073-1
PII: 10.1038/s41390-018-0073-1
Knihovny.cz E-resources
- MeSH
- Amniocentesis MeSH
- Biomarkers analysis MeSH
- Chlamydia trachomatis MeSH
- Chorioamnionitis MeSH
- Adult MeSH
- Fetal Blood chemistry MeSH
- Interleukin-6 analysis MeSH
- Humans MeSH
- Mycoplasma hominis MeSH
- Infant, Newborn MeSH
- Amniotic Fluid chemistry microbiology MeSH
- Fetal Membranes, Premature Rupture * MeSH
- Prospective Studies MeSH
- Syndrome MeSH
- Pregnancy MeSH
- Body Fluids MeSH
- Ureaplasma MeSH
- Gastric Juice chemistry microbiology MeSH
- Stomach microbiology MeSH
- Inflammation MeSH
- Check Tag
- Adult MeSH
- Humans MeSH
- Infant, Newborn MeSH
- Pregnancy MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Biomarkers MeSH
- IL6 protein, human MeSH Browser
- Interleukin-6 MeSH
OBJECTIVE: To determine changes in the intraamniotic environment during the latency period using paired amniotic and gastric fluid samples in pregnancies complicated by preterm prelabor rupture of membranes (PPROM). METHODS: A total of 34 women with singleton pregnancies complicated by PPROM prior to 34 weeks were included in the study. Amniotic fluid was obtained by transabdominal amniocentesis at the time of admission. Immediately after delivery, umbilical cord blood and gastric fluid were obtained. RESULT: Microorganisms in amniotic and gastric fluid samples were found in 38% and 59% of women, respectively. Bedside IL-6 levels were higher in amniotic than in gastric fluid in pregnancies without fetal inflammatory response syndrome (FIRS) (263 pg/mL vs. 50 pg/mL; p < 0.0001), but not in pregnancies with FIRS (318 pg/mL vs. 444 pg/mL; p = 0.91). Funisitis and FIRS was associated with the highest bedside IL-6 levels in gastric fluid. A gastric fluid bedside IL-6 level of 275 pg/mL was found to be the ideal cutoff value to predict funisitis and FIRS. CONCLUSIONS: The microbial and inflammatory status of the intraamniotic compartment changes during the latency period in PPROM. Bedside IL-6 assessment of gastric fluid may be useful in the rapid diagnosis of funisitis and FIRS.
Biomedical Research Center University Hospital Hradec Kralove Hradec Kralove Czech Republic
Department of Obstetrics and Gynecology Sahlgrenska Academy Gothenburg University Gothenburg Sweden
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