Gastric fluid used to assess changes during the latency period in preterm prelabor rupture of membranes
Jazyk angličtina Země Spojené státy americké Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
29892034
DOI
10.1038/s41390-018-0073-1
PII: 10.1038/s41390-018-0073-1
Knihovny.cz E-zdroje
- MeSH
- amniocentéza MeSH
- biologické markery analýza MeSH
- Chlamydia trachomatis MeSH
- chorioamnionitida MeSH
- dospělí MeSH
- fetální krev chemie MeSH
- interleukin-6 analýza MeSH
- lidé MeSH
- Mycoplasma hominis MeSH
- novorozenec MeSH
- plodová voda chemie mikrobiologie MeSH
- předčasný odtok plodové vody * MeSH
- prospektivní studie MeSH
- syndrom MeSH
- těhotenství MeSH
- tělesné tekutiny MeSH
- Ureaplasma MeSH
- žaludeční šťáva chemie mikrobiologie MeSH
- žaludek mikrobiologie MeSH
- zánět MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- novorozenec MeSH
- těhotenství MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- biologické markery MeSH
- IL6 protein, human MeSH Prohlížeč
- interleukin-6 MeSH
OBJECTIVE: To determine changes in the intraamniotic environment during the latency period using paired amniotic and gastric fluid samples in pregnancies complicated by preterm prelabor rupture of membranes (PPROM). METHODS: A total of 34 women with singleton pregnancies complicated by PPROM prior to 34 weeks were included in the study. Amniotic fluid was obtained by transabdominal amniocentesis at the time of admission. Immediately after delivery, umbilical cord blood and gastric fluid were obtained. RESULT: Microorganisms in amniotic and gastric fluid samples were found in 38% and 59% of women, respectively. Bedside IL-6 levels were higher in amniotic than in gastric fluid in pregnancies without fetal inflammatory response syndrome (FIRS) (263 pg/mL vs. 50 pg/mL; p < 0.0001), but not in pregnancies with FIRS (318 pg/mL vs. 444 pg/mL; p = 0.91). Funisitis and FIRS was associated with the highest bedside IL-6 levels in gastric fluid. A gastric fluid bedside IL-6 level of 275 pg/mL was found to be the ideal cutoff value to predict funisitis and FIRS. CONCLUSIONS: The microbial and inflammatory status of the intraamniotic compartment changes during the latency period in PPROM. Bedside IL-6 assessment of gastric fluid may be useful in the rapid diagnosis of funisitis and FIRS.
Biomedical Research Center University Hospital Hradec Kralove Hradec Kralove Czech Republic
Department of Obstetrics and Gynecology Sahlgrenska Academy Gothenburg University Gothenburg Sweden
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