Local low dose curcumin treatment improves functional recovery and remyelination in a rat model of sciatic nerve crush through inhibition of oxidative stress
Jazyk angličtina Země Anglie, Velká Británie Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
30018000
DOI
10.1016/j.neuropharm.2018.07.001
PII: S0028-3908(18)30356-3
Knihovny.cz E-zdroje
- Klíčová slova
- Curcumin, Myelin, Oxidative stress, Sciatic nerve crush,
- MeSH
- antioxidancia farmakologie MeSH
- drtivá poranění farmakoterapie patologie patofyziologie MeSH
- faktor 2 související s NF-E2 metabolismus MeSH
- kosterní svaly účinky léků patologie patofyziologie MeSH
- kultivované buňky MeSH
- kurkumin farmakologie MeSH
- náhodné rozdělení MeSH
- nervové vedení účinky léků MeSH
- nervus ischiadicus účinky léků zranění patologie patofyziologie MeSH
- neuroprotektivní látky farmakologie MeSH
- obnova funkce účinky léků fyziologie MeSH
- oxidační stres účinky léků MeSH
- peroxidace lipidů účinky léků MeSH
- potkani Sprague-Dawley MeSH
- remyelinizace účinky léků fyziologie MeSH
- simulace molekulární dynamiky MeSH
- zvířata MeSH
- Check Tag
- mužské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- antioxidancia MeSH
- faktor 2 související s NF-E2 MeSH
- kurkumin MeSH
- neuroprotektivní látky MeSH
- Nfe2l2 protein, rat MeSH Prohlížeč
Traumatic injuries to peripheral nerves are frequent, however, specific pharmacological treatments are currently lacking. Curcumin has antioxidant, anti-inflammatory and neuroprotective properties but high oral doses are required for therapeutic use, particularly due to its low bioavailability. The aim of the present study was to investigate the effects of local and continuous treatment using low curcumin doses on functional recovery and nerve regeneration after rat sciatic nerve crush (SNC). Curcumin was administered by osmotic pumps with a catheter delivering the drug at the injury site (0.2 mg/day for 4 weeks). Functionally, early improvements in mechanical sensitivity, finger spacing of the injured paw, skilful walking and grip strength were observed in curcumin-treated animals. The curcumin treatment increased expression of compact myelin proteins (MPZ and PMP22), myelin sheath thickness and, correspondingly, increased motor and sensitive nerve conduction velocity. Microscopic analysis of gastrocnemius muscle indicated a curcumin-induced decrease in neurogenic lesions. Curcumin treatment reduced the production of reactive oxygen species (ROS) (which were notably produced by macrophages), lipid peroxidation and increased expression of transcription factor Nrf2. In silico analyses indicated that curcumin combines all the characteristics required to be an efficient lipid peroxidation inhibitor at the heart of biological membranes, hence protecting their degradation due to ROS. This antioxidant capacity is likely to contribute to the beneficial effects of curcumin after SNC injury. These results demonstrate that, when administrated locally, low doses of curcumin represent a promising therapy for peripheral nerve regeneration.
Citace poskytuje Crossref.org
Oxidative Stress Evaluation in Ischemia Reperfusion Models: Characteristics, Limits and Perspectives
