Alterations in plasma acylcarnitine and amino acid profiles may indicate poor nutrition during the suckling period due to maternal intake of an unbalanced diet and may predict later metabolic dysfunction
Language English Country United States Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
- Keywords
- cafeteria diet, early biomarkers, perinatal nutrition, postcafeteria,
- MeSH
- Amino Acids blood MeSH
- Diet * MeSH
- Maternal Nutritional Physiological Phenomena * MeSH
- Liver metabolism MeSH
- Carnitine analogs & derivatives blood MeSH
- Animals, Suckling * MeSH
- Rats MeSH
- Lactation MeSH
- Metabolic Diseases etiology MeSH
- Lipid Metabolism MeSH
- Models, Animal MeSH
- Multivariate Analysis MeSH
- Nutritional Status * MeSH
- Pregnancy MeSH
- Prenatal Exposure Delayed Effects metabolism MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Pregnancy MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- acylcarnitine MeSH Browser
- Amino Acids MeSH
- Carnitine MeSH
Plasma profiles of acylcarnitines (ACs) and amino acids (AAs) may have interest as potential biomarkers. Here we analyzed plasma AC and AA profiles in 2 rat models with different metabolic programming outcomes: offspring of dams fed a cafeteria diet during lactation (O-CAF, with a thin-outside-fat-inside phenotype) and the offspring of dams with diet-induced obesity subjected to dietary normalization before gestation [offspring of postcafeteria dams (O-PCaf), nonaltered phenotype]. The purpose was to identify early variables that might indicate a propensity for a dysmetabolic state. O-CAF rats presented higher circulating levels of most of the lipid-derived ACs and higher hepatic expression of genes related to fatty acid oxidation ( Ppara and Cpt1a) than controls [offspring of control dams (O-C)]. They also exhibited an altered plasma AA profile. These differences were not observed in O-PCaf animals. A partial least squares-discriminant analysis score plot of the metabolomics data showed a clear separation between O-CAF and O-C animals. The long-chain ACs (C18, C18:1, C18:2, C16:1, and C16DC) and the AAs glycine, alanine, isoleucine, serine, and proline are the variables mainly influencing this separation. In summary, we have identified a cluster of ACs and AAs whose alterations may indicate poor nutrition during lactation due to maternal unbalanced diet intake and predict the later dysmetabolic phenotype observed in the offspring.-Pomar, C. A., Kuda, O., Kopecky, J., Rombaldova, M., Castro, H., Picó, C., Sánchez, J., Palou, A. Alterations in plasma acylcarnitine and amino acid profiles may indicate poor nutrition during the suckling period due to maternal intake of an unbalanced diet and may predict later metabolic dysfunction.
Facultad de Salud Pública y Nutrición Universidad Autónoma de Nuevo León Nuevo León Mexico; and
Instituto de Investigación Sanitaria Illes Balears Palma de Mallorca Spain
Laboratory of Molecular Biology Nutrition and Biotechnology Palma de Mallorca Spain
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