A cytotoxic tantalum(v) half-sandwich complex: a new challenge for metal-based anticancer agents
Language English Country Great Britain, England Media print
Document type Journal Article
PubMed
30094436
DOI
10.1039/c8cc05223a
Knihovny.cz E-resources
- MeSH
- Apoptosis drug effects MeSH
- Cytochromes c metabolism MeSH
- Hepatocytes drug effects MeSH
- Coordination Complexes chemical synthesis chemistry pharmacology toxicity MeSH
- Humans MeSH
- Ligands MeSH
- Membrane Potential, Mitochondrial drug effects MeSH
- Molecular Structure MeSH
- Cell Line, Tumor MeSH
- Organoplatinum Compounds pharmacology MeSH
- Oxaliplatin MeSH
- Antineoplastic Agents chemical synthesis chemistry pharmacology toxicity MeSH
- Reactive Nitrogen Species metabolism MeSH
- Reactive Oxygen Species metabolism MeSH
- Solubility MeSH
- Schiff Bases chemical synthesis chemistry MeSH
- Tantalum chemistry MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Cytochromes c MeSH
- Coordination Complexes MeSH
- Ligands MeSH
- Organoplatinum Compounds MeSH
- Oxaliplatin MeSH
- Antineoplastic Agents MeSH
- Reactive Nitrogen Species MeSH
- Reactive Oxygen Species MeSH
- Schiff Bases MeSH
- Tantalum MeSH
Despite the biological relevance of complexes of various transition metals, tantalum complexes have long been neglected by bioinorganic chemists. Herein, we demonstrate potential chemotherapeutic applicability of the [Ta(η5-Cp*)Cl2(salaph)] (1) complex, containing deprotonated Schiff base 2-{(E)-[(2-hydroxyphenyl)imino]methyl}phenol (H2salaph), which shows strong cytotoxicity in cancer cells, related to the induction of apoptosis and apoptosis-related processes, but shows low cytotoxicity in healthy cells.
References provided by Crossref.org
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