Artichoke leaf extract, as AKR1B1 inhibitor, decreases sorbitol level in the rat eye lenses under high glucose conditions ex vivo
Jazyk angličtina Země Velká Británie, Anglie Médium print-electronic
Typ dokumentu časopisecké články
Grantová podpora
APVV-15-0308
Agentúra Ministerstva školstva, vedy, výskumu a športu SR
APVV-16-0207
Agentúra Ministerstva školstva, vedy, výskumu a športu SR
FaF UK/6/2016
Faculty of Pharmacy, Comenius University in Bratislava
VEGA 1/0290/16
Ministerstvo školstva, vedy, výskumu a športu Slovenskej republiky
VEGA 1/0359/18
Ministerstvo školstva, vedy, výskumu a športu Slovenskej republiky
VEGA 1/0561/18
Ministerstvo školstva, vedy, výskumu a športu Slovenskej republiky
VEGA 2/0041/15
Ministerstvo školstva, vedy, výskumu a športu Slovenskej republiky
IGA VFU 313/2018/FaF
Veterinární a Farmaceutická Univerzita Brno
PubMed
30109747
DOI
10.1002/ptr.6174
Knihovny.cz E-zdroje
- Klíčová slova
- Cynara cardunculus, aldo-keto reductases, chronic diabetic complications, glucose toxicity, oxidative stress, polyol pathway,
- MeSH
- aldehydreduktasa antagonisté a inhibitory MeSH
- Cynara scolymus chemie MeSH
- glukosa farmakologie MeSH
- inhibitory enzymů farmakologie MeSH
- krysa rodu Rattus MeSH
- kultivované buňky MeSH
- listy rostlin chemie MeSH
- myši MeSH
- oční čočka účinky léků metabolismus MeSH
- orgánové kultury - kultivační techniky MeSH
- oxidační stres účinky léků MeSH
- reaktivní formy kyslíku farmakologie MeSH
- rostlinné extrakty farmakologie MeSH
- sorbitol metabolismus MeSH
- vztah mezi dávkou a účinkem léčiva MeSH
- zvířata MeSH
- Check Tag
- krysa rodu Rattus MeSH
- myši MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- Akr1b1 protein, rat MeSH Prohlížeč
- aldehydreduktasa MeSH
- glukosa MeSH
- inhibitory enzymů MeSH
- reaktivní formy kyslíku MeSH
- rostlinné extrakty MeSH
- sorbitol MeSH
In the previous study, the artichoke leaf extract showed effective inhibition of AKR1B1, the first enzyme of polyol pathway, which reduces high level of glucose to osmotically active sorbitol, important for development of chronic diabetic complications. In the present study, the effect of artichoke leaf extract and of several participating phenols (caffeic acid, chlorogenic acid, quinic acid, and luteolin) was tested on sorbitol level in rat lenses exposed to high glucose ex vivo, on cytotoxicity as well as on oxidative stress in C2C12 muscle cell line induced by high glucose in vitro. The concentration of sorbitol was determined by enzymatic analysis, the cytotoxicity was provided by WST-1 test and intracellular content of reactive oxygen species was determined by fluorescence of 2'-7'-dichlorofluorescein probe. The extract and the compounds tested showed significant protection against toxic effects of high concentration of glucose in both models. On balance, the artichoke leaf extract thus represents a prospective preventive agent of development of chronic diabetic complications, probably due to phenols content, concerning preclinical and clinical studies.
Department of Pharmacognosy and Botany Faculty of Pharmacy Comenius University Bratislava Slovakia
Institute of Experimental Pharmacology and Toxicology Slovak Academy of Sciences Bratislava Slovakia
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