Revaluation and lessons learned from the first 9 cases of a Czech uterus transplantation trial: Four deceased donor and 5 living donor uterus transplantations
Language English Country United States Media print-electronic
Document type Evaluation Study, Journal Article, Research Support, Non-U.S. Gov't
Grant support
00064203
Ministry of Health - International
Czech Republic - International
Conceptual Development of Research Organization - International
Motol University Hospital, Prague - International
PubMed
30151893
DOI
10.1111/ajt.15096
PII: S1600-6135(22)08997-3
Knihovny.cz E-resources
- Keywords
- clinical research/practice, donors and donation: deceased, donors and donation: living, obstetrics and gynecology, organ procurement, organ transplantation in general,
- MeSH
- Tissue Donors supply & distribution MeSH
- Adult MeSH
- Clinical Trials as Topic MeSH
- Middle Aged MeSH
- Humans MeSH
- Adolescent MeSH
- Young Adult MeSH
- Follow-Up Studies MeSH
- Tissue and Organ Harvesting methods MeSH
- Graft Survival MeSH
- Prognosis MeSH
- Death * MeSH
- Organ Transplantation methods MeSH
- Uterus transplantation MeSH
- Infertility, Female surgery MeSH
- Living Donors supply & distribution MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Adolescent MeSH
- Young Adult MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Evaluation Study MeSH
- Research Support, Non-U.S. Gov't MeSH
- Geographicals
- Czech Republic MeSH
Although uterus transplantation is still in the experimental stage, it has promising potential as a treatment for women with absolute uterine factor infertility based on the childbirths from living donor trials conducted in Sweden and the United States. We report the main characteristics and perioperative and postoperative courses of both recipients and donors following 4 deceased donor and 5 living donor uterus transplantations. Three main priorities differentiate this study from the previously reported uterus transplantations. First, clinical experience with the largest worldwide group of deceased donor uterine transplants is described. Second, in the majority of living donor uterine recipients, only 2 ovarian veins were used for venous blood outflow. All of these recipient procedures were surgically successful, and follow-up posttransplant ultrasound examinations revealed normal uterine blood supply and outflow. Third, in only one living and one deceased donor recipient, the transplanted uterus relied on only 2 uterine veins for venous outflow with a 50% surgical success rate. In all other recipients, 2 uterine and 2 ovarian veins were utilized. Although a successful pregnancy has not yet been achieved, the presented surgical and functional results of our trial are promising.
Department of Pathology Institute of Clinical and Experimental Medicine Prague Czech Republic
Transplantation Surgery Department Sahlgrenska University Hospital Gothenburg Sweden
References provided by Crossref.org
Deceased Donor Uterus Transplantation: A Narrative Review of the First 24 Published Cases
