Plethysmographic and biochemical markers in the diagnosis of endothelial dysfunction in pediatric acute lymphoblastic leukemia survivors - new applications
Jazyk angličtina Země Česko Médium print-electronic
Typ dokumentu časopisecké články
PubMed
30204466
DOI
10.33549/physiolres.933754
PII: 933754
Knihovny.cz E-zdroje
- MeSH
- akutní lymfatická leukemie krev diagnóza patofyziologie MeSH
- arginin analogy a deriváty krev MeSH
- biologické markery krev MeSH
- C-reaktivní protein metabolismus MeSH
- cévní endotel metabolismus patofyziologie MeSH
- dítě MeSH
- E-selektin krev MeSH
- lidé MeSH
- mladiství MeSH
- nemoci cév krev diagnóza patofyziologie MeSH
- pletysmografie metody MeSH
- prospektivní studie MeSH
- rizikové faktory MeSH
- Check Tag
- dítě MeSH
- lidé MeSH
- mladiství MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- arginin MeSH
- biologické markery MeSH
- C-reaktivní protein MeSH
- E-selektin MeSH
- N,N-dimethylarginine MeSH Prohlížeč
- SELE protein, human MeSH Prohlížeč
Acute lymphoblastic leukemia (ALL) and its treatment are associated with endothelial dysfunction (ED) and increased cardiovascular risk in adulthood. There are no data on ED in children after successful treatment of ALL. We aimed to assess new ED in these children using the plethysmographic reactive hyperemia index (RHI) and biomarkers that are known to be related to ED. In all, 22 children (mean 15.6 years), after successful treatment of ALL, and 18 healthy subjects were included in this prospective study. RHI, plasma concentrations of asymmetric dimethyl arginine (ADMA), high-sensitive CRP (hsCRP) and E-selectin were measured in all children. RHI values were significantly lower in ALL patients when compared with healthy controls (p<0.05). hsCRP was significantly increased in ALL patients compared with the control group (p<0.001). E-selectin plasma levels were higher in ALL patients as compared to healthy controls (p=0.05). This is the first study that combines both plethysmographic and biochemical methods to assess ED in ALL survivors. Significantly decreased RHI with elevated plasma concentrations of biochemical markers imply a possible association with premature ED in ALL patients. The combined diagnostic approach seems to be a valuable tool for more accurate detection of ED and preventive cardiovascular management in these patients.
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