Heart rate reduction after ivabradine might be associated with reverse electrical remodeling in patients with cardiomyopathy and left bundle branch block

. 2018 Nov ; 46 (11) : 4825-4828. [epub] 20180918

Jazyk angličtina Země Velká Británie, Anglie Médium print-electronic

Typ dokumentu kazuistiky, časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/pmid30223689

Left bundle branch block increases the risk of death in patients with chronic heart failure. We herein report four clinical cases of patients with chronic heart failure caused by nonischemic cardiomyopathy with left bundle branch block that occurred when adding ivabradine to optimal medical therapy, resulting in reverse electrical and mechanical remodeling. This phenomenon might be explained by the effect of ivabradine on reverse remodeling of the left ventricle with improvement of intraventricular conduction.

Zobrazit více v PubMed

Reil JC, Robertson M, Ford I, et al. Impact of left bundle branch block on heart rate and its relationship to treatment with ivabradine in chronic heart failure. Eur J Heart Fail 2013; 15: 1044–1052. PubMed

Navaratnarajah M, Ibrahim M, Siedlecka U, et al. Influence of ivabradine on reverse remodeling during mechanical unloading. Cardiovasc Res 2013; 97: 230–239. PubMed

Milliez P, Messaoudi S, Nehme J, et al. Beneficial effects of delayed ivabradine treatment on cardiac anatomical and electrical remodeling in rat severe chronic heart failure. Am J Physiol Heart Circ 2009; 296: H435–H441. PubMed

Tardif JC, O'Meara E, Komajda M, et al. Effects of selective heart rate reduction with ivabradine on left ventricular remodelling and function: results from the SHIFT echocardiography substudy. Eur Heart J 2011; 32: 2507–2515. DOI:10.1093/eurheartj/ehr311 PubMed PMC

Kloosterman M, Riebstra M, Van Gelder IC, et al. Spontaneous resolution of left bundle branch block and biventricular stimulation lead to reverse remodeling in dyssynchronopathy. J Electrocardiol 2016; 49: 696–698. PubMed

Sebag FA, Martins RP, Defaye P, et al. Reverse electrical remodeling by cardiac resynchronization therapy: prevalence and clinical impact. J Cardiovasc Electrophysiol 2012; 23: 1219–1227. PubMed

Drakos SG, Terrovitis JV, Nanas JN, et al. Reverse electrophysiologic remodeling after cardiac mechanical unloading for end-stage nonischemic cardiomyopathy. Ann Thorac Surg 2011; 91: 764–769. PubMed

Najít záznam

Citační ukazatele

Nahrávání dat ...

Možnosti archivace

Nahrávání dat ...