Heart rate reduction after ivabradine might be associated with reverse electrical remodeling in patients with cardiomyopathy and left bundle branch block
Jazyk angličtina Země Velká Británie, Anglie Médium print-electronic
Typ dokumentu kazuistiky, časopisecké články
PubMed
30223689
PubMed Central
PMC6259405
DOI
10.1177/0300060518799566
Knihovny.cz E-zdroje
- Klíčová slova
- Electrical remodeling, cardiomyopathy, chronic heart failure, intraventricular conduction, ivabradine, left bundle branch block,
- MeSH
- blokáda Tawarova raménka komplikace diagnostické zobrazování farmakoterapie patofyziologie MeSH
- dospělí MeSH
- elektrokardiografie MeSH
- ivabradin farmakologie terapeutické užití MeSH
- kardiomyopatie komplikace diagnostické zobrazování farmakoterapie patofyziologie MeSH
- lidé středního věku MeSH
- lidé MeSH
- remodelace síní účinky léků MeSH
- senioři MeSH
- srdeční frekvence účinky léků MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- kazuistiky MeSH
- Názvy látek
- ivabradin MeSH
Left bundle branch block increases the risk of death in patients with chronic heart failure. We herein report four clinical cases of patients with chronic heart failure caused by nonischemic cardiomyopathy with left bundle branch block that occurred when adding ivabradine to optimal medical therapy, resulting in reverse electrical and mechanical remodeling. This phenomenon might be explained by the effect of ivabradine on reverse remodeling of the left ventricle with improvement of intraventricular conduction.
Zobrazit více v PubMed
Reil JC, Robertson M, Ford I, et al. Impact of left bundle branch block on heart rate and its relationship to treatment with ivabradine in chronic heart failure. Eur J Heart Fail 2013; 15: 1044–1052. PubMed
Navaratnarajah M, Ibrahim M, Siedlecka U, et al. Influence of ivabradine on reverse remodeling during mechanical unloading. Cardiovasc Res 2013; 97: 230–239. PubMed
Milliez P, Messaoudi S, Nehme J, et al. Beneficial effects of delayed ivabradine treatment on cardiac anatomical and electrical remodeling in rat severe chronic heart failure. Am J Physiol Heart Circ 2009; 296: H435–H441. PubMed
Tardif JC, O'Meara E, Komajda M, et al. Effects of selective heart rate reduction with ivabradine on left ventricular remodelling and function: results from the SHIFT echocardiography substudy. Eur Heart J 2011; 32: 2507–2515. DOI:10.1093/eurheartj/ehr311 PubMed PMC
Kloosterman M, Riebstra M, Van Gelder IC, et al. Spontaneous resolution of left bundle branch block and biventricular stimulation lead to reverse remodeling in dyssynchronopathy. J Electrocardiol 2016; 49: 696–698. PubMed
Sebag FA, Martins RP, Defaye P, et al. Reverse electrical remodeling by cardiac resynchronization therapy: prevalence and clinical impact. J Cardiovasc Electrophysiol 2012; 23: 1219–1227. PubMed
Drakos SG, Terrovitis JV, Nanas JN, et al. Reverse electrophysiologic remodeling after cardiac mechanical unloading for end-stage nonischemic cardiomyopathy. Ann Thorac Surg 2011; 91: 764–769. PubMed