EEG coherence in a mental arithmetic task performance in first episode schizophrenia and schizoaffective disorder
Jazyk angličtina Země Nizozemsko Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
30240977
DOI
10.1016/j.clinph.2018.08.020
PII: S1388-2457(18)31214-8
Knihovny.cz E-zdroje
- Klíčová slova
- EEG coherence, First psychotic episode, Mental arithmetic task, Resting state, Schizoaffective disorder, Schizophrenia,
- MeSH
- dospělí MeSH
- inteligenční testy MeSH
- kognice * MeSH
- lidé MeSH
- matematika MeSH
- mladiství MeSH
- mozkové vlny * MeSH
- psychotické poruchy patofyziologie MeSH
- schizofrenie patofyziologie MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- mladiství MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
OBJECTIVES: To evaluate the coherence values of the cortical bands in patients with first episode schizophrenia and schizoaffective disorder during the performance of a mental arithmetic task. METHOD: We analysed EEG coherence in the resting state and subsequently while counting down from 200 in steps of 7 in 32 first episode schizophrenia patients (SZ), 32 patients with first episode schizoaffective disorder (SA) and 40 healthy controls (HC). RESULTS: Task performance in HC is characterised by decreased coherence in the alpha bands and increased coherence in the beta 2 and gamma bands in frontal sites. In SZ, coherence decreases in the alpha band, whereas in SA it substantially increases in the alpha, beta1, beta 2 and gamma bands. CONCLUSIONS: Despite no differences in performance on a behavioural level, SA patients demonstrate a paradoxical increase in both low and fast frequency bands during the performance of a mental arithmetic task, while, patients with SZ show a decreased coherence in the alpha band, presumably alluding to the excessive excitatory (in SA) and inhibitory (in SZ) mechanisms in cognitive processing. SIGNIFICANCE: The current study provides evidence for the distinction of neurophysiological mechanisms of cognitive processing between SZ and SA.
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