Structural and copy number chromosome abnormalities in canine cutaneous mast cell tumours

. 2019 Feb ; 60 (1) : 63-70. [epub] 20181004

Jazyk angličtina Země Anglie, Velká Británie Médium print-electronic

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/pmid30284681

Grantová podpora
16-26655S Grantová Agentura České Republiky
RO 0516 Ministerstvo Zemědělství
CEITEC 2020 LQ1601 Ministerstvo Školství, Mládeže a Tělovýchovy

Odkazy

PubMed 30284681
DOI 10.1007/s13353-018-0471-4
PII: 10.1007/s13353-018-0471-4
Knihovny.cz E-zdroje

Mast cell tumours (MCTs) are the most common skin tumours in dogs. Their clinical behaviour is variable and their aetiology remains largely unknown. We performed a metaphase fluorescence in situ hybridisation (FISH) with whole chromosome painting probes, and interphase FISH with BAC probes for 14 cancer-related genes to reveal clonal structural chromosome rearrangements and copy number variants (CNVs) in canine cutaneous MCTs. The metaphase FISH performed in three MCTs revealed several clonal monosomies and trisomies and two different chromosome rearrangements. No centric fusions were detected. The interphase FISH showed a variety of low frequency CNVs for the individual cancer-related genes. The heterogeneous character of the detected abnormalities indicates increased chromosome instability in canine MCTs. The clonal gain of chromosome 11 was detected in 81% (13/16) of the MCTs. Further research is needed to evaluate the significance of this abnormality as prognostic factor for the survival time or recurrence risk assessments in canine cutaneous MCTs.

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