Recurrent aphthous stomatitis and gene variability in selected interleukins: a case-control study
Jazyk angličtina Země Velká Británie, Anglie Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
30341786
DOI
10.1111/eos.12577
Knihovny.cz E-zdroje
- Klíčová slova
- association studies, candidate gene, genetic, immunity, oral ulcer, polymorphisms,
- MeSH
- aftózní stomatitida epidemiologie imunologie MeSH
- alely MeSH
- dospělí MeSH
- frekvence genu MeSH
- genetická predispozice k nemoci MeSH
- genetická variace * MeSH
- genotyp MeSH
- haplotypy MeSH
- interleukin-10 genetika metabolismus MeSH
- interleukin-13 genetika metabolismus MeSH
- interleukin-2 genetika MeSH
- interleukin-4 genetika metabolismus MeSH
- interleukiny genetika metabolismus MeSH
- lidé středního věku MeSH
- lidé MeSH
- molekulární epidemiologie * MeSH
- polymerázová řetězová reakce MeSH
- polymorfismus genetický MeSH
- receptor interleukinu-4 - alfa-podjednotka genetika metabolismus MeSH
- studie případů a kontrol MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Geografické názvy
- Česká republika epidemiologie MeSH
- Názvy látek
- IL10 protein, human MeSH Prohlížeč
- IL2 protein, human MeSH Prohlížeč
- IL4 protein, human MeSH Prohlížeč
- IL4R protein, human MeSH Prohlížeč
- interleukin-10 MeSH
- interleukin-13 MeSH
- interleukin-2 MeSH
- interleukin-4 MeSH
- interleukiny MeSH
- receptor interleukinu-4 - alfa-podjednotka MeSH
Genetic factors, especially those related to immune system functioning, have been intensively studied to determine their role in the development of recurrent aphthous stomatitis (RAS). The aim of the present study was to analyze gene variability in interleukin (IL)2, IL4 (and its receptor α, IL4Rα), IL10, and IL13, which were selected based on literature review and/or their functional relevance, in Czech patients with RAS and in healthy controls. In total, 252 subjects (178 controls and 74 patients with RAS) were enrolled in this case-control study, and their detailed anamnestic, clinical, and laboratory data were obtained. Nine polymorphisms in the genes encoding interleukins were determined using PCR techniques. There were no significant differences in allele or genotype frequencies of the IL2, IL4, IL4Rα, IL10, and IL13 polymorphisms rs2069762/rs2069763, rs2243250/rs79071878, rs1801275, rs1800896, and rs1800925, respectively, between controls and patients with RAS. The minority alleles rs1800871 and rs1800872, which encode variants of IL10, were associated with a statistically significantly higher risk of RAS, as confirmed by the results of genotype and haplotype analyses. We suggest that variability in the IL10 gene may play an important role in the development of RAS in the Czech population.
Department of Pathophysiology Faculty of Medicine Masaryk University Brno Czech Republic
Institute of Biostatistics and Analyses Masaryk University Brno Czech Republic
Citace poskytuje Crossref.org
