Recurrent aphthous stomatitis and gene variability in selected interleukins: a case-control study
Language English Country Great Britain, England Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
30341786
DOI
10.1111/eos.12577
Knihovny.cz E-resources
- Keywords
- association studies, candidate gene, genetic, immunity, oral ulcer, polymorphisms,
- MeSH
- Stomatitis, Aphthous epidemiology immunology MeSH
- Alleles MeSH
- Adult MeSH
- Gene Frequency MeSH
- Genetic Predisposition to Disease MeSH
- Genetic Variation * MeSH
- Genotype MeSH
- Haplotypes MeSH
- Interleukin-10 genetics metabolism MeSH
- Interleukin-13 genetics metabolism MeSH
- Interleukin-2 genetics MeSH
- Interleukin-4 genetics metabolism MeSH
- Interleukins genetics metabolism MeSH
- Middle Aged MeSH
- Humans MeSH
- Molecular Epidemiology * MeSH
- Polymerase Chain Reaction MeSH
- Polymorphism, Genetic MeSH
- Interleukin-4 Receptor alpha Subunit genetics metabolism MeSH
- Case-Control Studies MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Geographicals
- Czech Republic epidemiology MeSH
- Names of Substances
- IL10 protein, human MeSH Browser
- IL2 protein, human MeSH Browser
- IL4 protein, human MeSH Browser
- IL4R protein, human MeSH Browser
- Interleukin-10 MeSH
- Interleukin-13 MeSH
- Interleukin-2 MeSH
- Interleukin-4 MeSH
- Interleukins MeSH
- Interleukin-4 Receptor alpha Subunit MeSH
Genetic factors, especially those related to immune system functioning, have been intensively studied to determine their role in the development of recurrent aphthous stomatitis (RAS). The aim of the present study was to analyze gene variability in interleukin (IL)2, IL4 (and its receptor α, IL4Rα), IL10, and IL13, which were selected based on literature review and/or their functional relevance, in Czech patients with RAS and in healthy controls. In total, 252 subjects (178 controls and 74 patients with RAS) were enrolled in this case-control study, and their detailed anamnestic, clinical, and laboratory data were obtained. Nine polymorphisms in the genes encoding interleukins were determined using PCR techniques. There were no significant differences in allele or genotype frequencies of the IL2, IL4, IL4Rα, IL10, and IL13 polymorphisms rs2069762/rs2069763, rs2243250/rs79071878, rs1801275, rs1800896, and rs1800925, respectively, between controls and patients with RAS. The minority alleles rs1800871 and rs1800872, which encode variants of IL10, were associated with a statistically significantly higher risk of RAS, as confirmed by the results of genotype and haplotype analyses. We suggest that variability in the IL10 gene may play an important role in the development of RAS in the Czech population.
Department of Pathophysiology Faculty of Medicine Masaryk University Brno Czech Republic
Institute of Biostatistics and Analyses Masaryk University Brno Czech Republic
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