BACKGROUND: In collaboration with United European Gastroenterology, the working group on 'Harmonizing diagnosis and treatment of chronic pancreatitis across Europe' (HaPanEU) developed European guidelines for the management of chronic pancreatitis using an evidence-based approach. METHODS: Recommendations of multidisciplinary review groups based on systematic literature reviews to answer predefined clinical questions are summarised. Recommendations are graded using the Grading of Recommendations Assessment, Development and Evaluation system. RESULTS: Recommendations covered topics related to the clinical management of chronic pancreatitis: aetiology, diagnosis of chronic pancreatitis with imaging, diagnosis of pancreatic exocrine insufficiency, surgical therapy, medical therapy, endoscopic therapy, treatment of pancreatic pseudocysts, pancreatic pain, nutrition and malnutrition, diabetes mellitus and the natural course of the disease and quality of life. CONCLUSIONS: The HaPanEU/United European Gastroenterology guidelines provide evidence-based recommendations concerning key aspects of the medical and surgical management of chronic pancreatitis based on current available evidence. These recommendations should serve as a reference standard for existing management of the disease and as a guide for future clinical research. This article summarises the HaPanEU recommendations and statements.

1st Department of Medicine University of Szeged Szeged Hungary

Center for Digestive Diseases Karolinska University Hospital Stockholm Sweden

Centre for Pancreatic Diseases Department of Gastroenterology Aalborg University Hospital Denmark

Department of Gastroenterology and Hepatology Health Research Institute University Hospital of Santiago de Compostela Spain

Department of Internal Medicine 1 Martin Luther University Halle Germany

Department of Internal Medicine General Hospital Luebbecke Rahden Luebbecke Justus Liebig University Giessen Giessen Germany

Institute of Medicine Sahlgrenska Academy University of Gothenburg Gothenburg Sweden

Pancreatology. 2020 Jan;20(1):148. doi: 10.1016/j.pan.2019.10.005. PubMed   Okhlobystiy, Alexey V [corrected to Okhlobystin, Alexey V]

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Causes of Exocrine Pancreatic Insufficiency Other Than Chronic Pancreatitis

European guidelines on chronic mesenteric ischaemia - joint United European Gastroenterology, European Association for Gastroenterology, Endoscopy and Nutrition, European Society of Gastrointestinal and Abdominal Radiology, Netherlands Association of Hepatogastroenterologists, Hellenic Society of Gastroenterology, Cardiovascular and Interventional Radiological Society of Europe, and Dutch Mesenteric Ischemia Study group clinical guidelines on the diagnosis and treatment of patients with chronic mesenteric ischaemia