Symptomatic respiratory Encephalitozoon cuniculi infection in renal transplant recipients
Jazyk angličtina Země Kanada Médium print-electronic
Typ dokumentu časopisecké články
PubMed
30391325
DOI
10.1016/j.ijid.2018.10.016
PII: S1201-9712(18)34562-4
Knihovny.cz E-zdroje
- Klíčová slova
- Encephalitozoon cuniculi, Enterocytozoon bieneusi, Life-long immunosuppression, Renal transplant recipients, Respiratory tract,
- MeSH
- dospělí MeSH
- Encephalitozoon cuniculi * genetika izolace a purifikace MeSH
- encephalitozoonóza mikrobiologie MeSH
- Enterocytozoon genetika izolace a purifikace MeSH
- imunokompromitovaný pacient * MeSH
- infekce dýchací soustavy mikrobiologie MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladý dospělý MeSH
- příjemce transplantátu MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- transplantace ledvin * MeSH
- zvířata MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
OBJECTIVES: Encephalitozoon spp. and Enterocytozoon bieneusi are intracellular parasitic fungi from the phylum Microsporidia, which initially localize to the intestine. As opportunistic pathogens, Encephalitozoon spp. in particular can disseminate to the respiratory tract, among other locations. Patients on life-long immunosuppression are at higher risk of such infections, mostly symptomatic. METHODS: Sputum samples and bronchial washings from 72 renal transplant recipients and 105 patients with various respiratory diseases were screened for Encephalitozoon spp. and E. bieneusi by microscopic examination and genus-specific nested PCR followed by genotyping. RESULTS: A total of 8.3% (6/72) of immunosuppressed renal transplant recipients and 1.9% (2/105) of patients with various respiratory diseases, both immunocompetent and immunosuppressed, were positive for respiratory microsporidial infection. All six transplant recipients were Encephalitozoon cuniculi-positive by PCR/sequencing and five of them suffered from respiratory symptoms. The presence of microsporidial spores was also confirmed microscopically in three of the transplant recipients. Of the two immunocompetent patients with various respiratory diseases, one had an E. cuniculi infection, while the second had an E. bieneusi infection. CONCLUSIONS: Life-long immunosuppression in renal transplant recipients increases the risk of respiratory infection by E. cuniculi. Microsporidia should be screened in respiratory samples of these patients, particularly when they have respiratory symptoms.
Citace poskytuje Crossref.org
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Encephalitozoon cuniculi Genotype II Concentrates in Inflammation Foci
