A lip cream with special propolis extract GH 2002 at a concentration of 0.5% (199 patients) was tested against aciclovir 5% (198 patients) in the treatment of episodes of herpes labialis under double-blind conditions. Upon inclusion, all patients were in the vesicular phase. Application was five times daily of approximately 0.2 g of cream to the entire upper and lower lip. The primary parameter was the difference in time between groups to complete encrustation or epithelization of the lesions. Secondary endpoints were the course of typical herpes symptoms (pain, burning and itching, tension and swelling), the global assessment of efficacy and the safety of application. The predefined clinical situation was reached after a (median) 3 days with propolis and 4 days with aciclovir (p < 0.0001). Significant differences in favor of propolis were also found for all secondary parameters. No allergic reactions, local irritations or other adverse events occurred.

Unter Doppelblindbedingungen wurde eine Lippencreme mit 0,5 % Propolis-Spezialextrakt GH 2002 (199 Patienten) gegen eine Creme mit 5 % Aciclovir (198 Patienten) bei der Behandlung von Episoden des Herpes labialis getestet. Bei Einschluss waren alle Patienten in der vesikulären Phase. Die Anwendung der Creme erfolgte 5‑mal täglich mit je etwa 0,2 g auf die gesamte Ober- und Unterlippe. Als primärer Endpunkt war der Gruppenunterschied in der Zeit bis zur vollständigen Verkrustung oder Epithelisierung der Läsionen definiert. Sekundäre Endpunkte waren der Verlauf der typischen Herpessymptome (Schmerzen, Brennen und Jucken, Spannung und Schwellung), die Gesamtbewertung der Wirksamkeit und die Anwendungssicherheit. Die vordefinierte klinische Situation wurde unter Propolis nach (im Median) 3 Tagen und mit Aciclovir nach 4 Tagen erreicht (p < 0,0001). Signifikante Unterschiede zugunsten von Propolis zeigten sich auch bei allen sekundären Endpunkten. Es traten weder allergische Reaktionen noch lokale Irritationen oder andere Nebenwirkungen auf.

Department of Dermatology Medical University of Kosice Trieda SNP 1 04011 Kosice Slovakia

Department of Medical Informatics 2nd Facultyof Medicine Charles University of Prague V Úvalu 84 15006 Prague Czech Republic

Dermatological Clinic DOST Dr Pribulu 2 08901 Svidnik Slovakia

Dermatology Ambulance Bernolakova 2476 95501 Topolcany Slovakia

Dermatology Department 1st Private Hospital Lucna 57 04015 Kosice Slovakia

Policlinica 2 Dermatology Ambulance C Spanyola 43 01001 Zilina Slovakia

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