Osteoporosis complicating some inborn or acquired diseases
Language English Country Czech Republic Media print
Document type Journal Article, Review
PubMed
30484671
DOI
10.33549/physiolres.934027
PII: 934027
Knihovny.cz E-resources
- MeSH
- Celiac Disease complications genetics metabolism MeSH
- Crohn Disease complications genetics metabolism MeSH
- Diabetes Mellitus genetics metabolism MeSH
- Humans MeSH
- Metabolic Diseases complications genetics metabolism MeSH
- Osteoporosis complications genetics metabolism MeSH
- Bone Remodeling physiology MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Review MeSH
Osteoporosis in chronic diseases is very frequent and pathogenetically varied. It complicates the course of the underlying disease by the occurrence of fractures, which aggravate the quality of life and increase the mortality of patients from the underlying disease. The secondary deterioration of bone quality in chronic diseases, such as diabetes of type 1 and type 2 and/or other endocrine and metabolic disorders, as well as inflammatory diseases, including rheumatoid arthritis - are mostly associated with structural changes to collagen, altered bone turnover, increased cortical porosity and damage to the trabecular and cortical microarchitecture. Mechanisms of development of osteoporosis in some inborn or acquired disorders are discussed.
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