Glibenclamide, a drug used for the treatment of type 2 diabetes, belongs to Class II of Biopharmaceutical Classification System. It is a highly permeable, but poorly water-soluble drug. Nanoparticles of glibenclamide were prepared by an emulsion solvent evaporation method using dichloromethane as a solvent of glibenclamide and 3% (w/w) aqueous solution of carboxymethyl dextran sodium salt as a stabilizer, which was found as optimal. A solubility test comparing the water solubility of glibenclamide bulk and nanoparticles confirmed the improved (2-fold higher) solubility of glibenclamide nanoparticles (0.045 μg/ml) compared with bulk (0.024 μg/ml).

Department of Chemical Drugs Faculty of Pharmacy University of Veterinary and Pharmaceutical Sciences Palackeho 1 612 42 Brno Czech Republic

Department of Chemical Theory of Drugs Faculty of Pharmacy Comenius University Kalinciakova 8 832 32 Bratislava Slovakia

Department of Pharmaceutical Chemistry Faculty of Pharmacy Comenius University Odbojarov 10 832 32 Bratislava Slovakia

Nanotechnology Centre VŠ B Technical University of Ostrava 17 listopadu 15 2172 708 33 Ostrava Poruba Czech Republic

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