Improvement of Glibenclamide Water Solubility by Nanoparticle Preparation
Status PubMed-not-MEDLINE Language English Country United States Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
Glibenclamide, a drug used for the treatment of type 2 diabetes, belongs to Class II of Biopharmaceutical Classification System. It is a highly permeable, but poorly water-soluble drug. Nanoparticles of glibenclamide were prepared by an emulsion solvent evaporation method using dichloromethane as a solvent of glibenclamide and 3% (w/w) aqueous solution of carboxymethyl dextran sodium salt as a stabilizer, which was found as optimal. A solubility test comparing the water solubility of glibenclamide bulk and nanoparticles confirmed the improved (2-fold higher) solubility of glibenclamide nanoparticles (0.045 μg/ml) compared with bulk (0.024 μg/ml).
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