Haloperidol affects coupling between QT and RR intervals in guinea pig isolated heart
Language English Country Japan Media print-electronic
Document type Journal Article
PubMed
30528680
DOI
10.1016/j.jphs.2018.11.004
PII: S1347-8613(18)30205-6
Knihovny.cz E-resources
- Keywords
- Drug-induced QT prolongation, Guinea pig, Haloperidol, Isolated heart, QT/RR coupling,
- MeSH
- Antipsychotic Agents pharmacology MeSH
- Haloperidol pharmacology MeSH
- Guinea Pigs MeSH
- Heart drug effects physiology MeSH
- Heart Rate drug effects MeSH
- Long QT Syndrome MeSH
- Animals MeSH
- Check Tag
- Guinea Pigs MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Antipsychotic Agents MeSH
- Haloperidol MeSH
Prolonged QT interval is an independent risk factor for development of ventricular arrhythmias. Haloperidol is one of the drugs inducing QT prolongation. Previous studies showed that haloperidol affects not only QT duration but also heart rate (RR interval). The present work focused on relationship between QT and RR and its changes under acute and chronic haloperidol administration. The study included 14 male guinea pigs divided into control and haloperidol-treated group. After 21-days administration of haloperidol or vehiculum, electrograms in isolated hearts were recorded. QT/RR and dQT/dRR coupling were calculated. Chronic haloperidol administration significantly decreases the coupling between QT and RR. Acute haloperidol exposure significantly decreases the dQT/dRR coupling in both treated and untreated guinea pig hearts. Flatter QT/RR relationship reveals a lack of QT adaptation to increased heart rate. It should be emphasized that in such situation ECG recording will not show significant QT prolongation evaluated according to clinical rules. However, if QT interval does not adapt to increased heart rate sufficiently, the risk of ventricular arrhythmias may be increased despite practically normal QT interval length. The results are supported by findings in biochemical analyses, which proved eligibility of the used model.
Department of Biochemistry Faculty of Medicine Masaryk University Brno Czech Republic
Department of Biomedical Engineering Brno University of Technology Brno Czech Republic
Department of Physiology Faculty of Medicine Masaryk University Brno Czech Republic
Institute of Scientific Instruments Academy of Sciences Brno Czech Republic
References provided by Crossref.org
Anesthetized guinea pig as a model for drug testing
Golden Standard or Obsolete Method? Review of ECG Applications in Clinical and Experimental Context
