Evidence of functional Cd94 polymorphism in a free-living house mouse population
Jazyk angličtina Země Spojené státy americké Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
30535636
DOI
10.1007/s00251-018-01100-x
PII: 10.1007/s00251-018-01100-x
Knihovny.cz E-zdroje
- Klíčová slova
- Comparative immunology/evolution, Genomics, Inhibitory/activating receptors, MHC, NK cell,
- MeSH
- alely MeSH
- buňky NK metabolismus MeSH
- CD8-pozitivní T-lymfocyty metabolismus MeSH
- CHO buňky MeSH
- Cricetulus MeSH
- druhová specificita MeSH
- HEK293 buňky MeSH
- křečci praví MeSH
- lektinové receptory NK-buněk - podrodina C chemie genetika metabolismus MeSH
- lektinové receptory NK-buněk - podrodina D chemie genetika metabolismus MeSH
- lidé MeSH
- MHC antigeny I. třídy chemie genetika metabolismus MeSH
- multimerizace proteinu MeSH
- myši inbrední C57BL MeSH
- myši inbrední DBA MeSH
- peptidy chemie genetika metabolismus MeSH
- polymorfismus genetický * MeSH
- sekvence aminokyselin MeSH
- sekvenční homologie aminokyselin MeSH
- vazba proteinů MeSH
- zvířata MeSH
- Check Tag
- křečci praví MeSH
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Geografické názvy
- Norsko MeSH
- Názvy látek
- lektinové receptory NK-buněk - podrodina C MeSH
- lektinové receptory NK-buněk - podrodina D MeSH
- MHC antigeny I. třídy MeSH
- peptidy MeSH
- Q surface antigens MeSH Prohlížeč
- Qdm protein, mouse MeSH Prohlížeč
The CD94 receptor, expressed on natural killer (NK) and CD8+ T cells, is known as a relatively non-polymorphic receptor with orthologues in humans, other primates, cattle, and rodents. In the house mouse (Mus musculus), a single allele is highly conserved among laboratory strains, and reports of allelic variation in lab- or wild-living mice are lacking, except for deficiency in one lab strain (DBA/2J). The non-classical MHC-I molecule Qa-1b is the ligand for mouse CD94/NKG2A, presenting alternative non-americ fragment of leader peptides (Qa-1 determinant modifier (Qdm)) from classical MHC-I molecules. Here, we report a novel allele identified in free-living house mice captured in Norway, living among individuals carrying the canonical Cd94 allele. The novel Cd94LocA allele encodes 12 amino acid substitutions in the extracellular lectin-like domain. Flow cytometric analysis of primary NK cells and transfected cells indicates that the substitutions prevent binding of CD94 mAb and Qa-1b/Qdm tetramers. Our data further indicate correlation of Cd94 polymorphism with the two major subspecies of house mice in Europe. Together, these findings suggest that the Cd94LocA/NKG2A heterodimeric receptor is widely expressed among M. musculus subspecies musculus, with ligand-binding properties different from mice of subspecies domesticus, such as the C57BL/6 strain.
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Immunogenetics. 1999 Jul;49(7-8):712-7 PubMed
Proc Natl Acad Sci U S A. 1998 May 26;95(11):6320-5 PubMed
Immunogenetics. 2004 Dec;56(9):639-49 PubMed
Mamm Genome. 2004 Nov;15(11):924-34 PubMed
J Immunol. 2002 Jan 1;168(1):240-52 PubMed
J Exp Med. 1999 Dec 20;190(12):1801-12 PubMed
Res Immunol. 1996 Jun;147(5):286-90 PubMed
Int J Parasitol. 2013 Sep;43(10):805-17 PubMed
Nat Immunol. 2002 Feb;3(2):189-95 PubMed
Immunity. 2011 Apr 22;34(4):579-89 PubMed
Proc Natl Acad Sci U S A. 2002 Jan 22;99(2):868-73 PubMed
Immunol Res. 2004;30(1):29-34 PubMed
Nat Immunol. 2008 May;9(5):495-502 PubMed
Eur J Immunol. 1998 Dec;28(12):4356-61 PubMed
Immunogenetics. 2007 Apr;59(4):273-80 PubMed
Eur J Immunol. 1997 Aug;27(8):2080-6 PubMed
Trends Genet. 2003 Jan;19(1):24-31 PubMed
J Immunol. 2011 Dec 15;187(12):6365-73 PubMed
Proc Biol Sci. 2009 Jan 22;276(1655):209-17 PubMed
Nat Genet. 2011 May 29;43(7):648-55 PubMed
Folia Biol (Praha). 2000;46(1):31-41 PubMed
PLoS Genet. 2009 Oct;5(10):e1000688 PubMed
Nature. 1998 Feb 19;391(6669):795-9 PubMed
J Exp Med. 1998 Nov 16;188(10):1841-8 PubMed
J Immunol. 2003 Oct 15;171(8):4219-26 PubMed
Immunol Today. 1990 Jul;11(7):237-44 PubMed
Eur J Immunol. 1997 Dec;27(12):3236-41 PubMed
J Exp Med. 2000 Sep 4;192(5):613-24 PubMed
J Mol Biol. 2000 Sep 8;302(1):205-17 PubMed
Curr Top Microbiol Immunol. 1986;127:272-8 PubMed
Proc Natl Acad Sci U S A. 1998 Apr 28;95(9):5199-204 PubMed
PLoS One. 2017 Aug 2;12(8):e0182296 PubMed
J Immunol. 2008 Jan 1;180(1):25-9 PubMed
Mol Ecol. 2010 Dec;19(23):5252-64 PubMed
Mol Ecol. 2011 Dec;20(23):5103-10 PubMed
Immunity. 2015 Dec 15;43(6):1112-24 PubMed
Front Immunol. 2014 Mar 26;5:123 PubMed
Nat Genet. 2000 Jan;24(1):23-5 PubMed
PLoS One. 2010 Dec 03;5(12):e15184 PubMed
Mol Ecol. 2011 Dec;20(24):5248-64 PubMed
J Immunol. 2006 May 1;176(9):5478-85 PubMed
Annu Rev Immunol. 2002;20:853-85 PubMed
Immunogenetics. 2017 Apr;69(4):255-269 PubMed
Immunol Res. 2006;35(3):263-78 PubMed
J Immunol. 1990 Mar 15;144(6):2400-8 PubMed
Cell. 1994 Nov 18;79(4):649-58 PubMed
J Immunol. 2012 Jan 1;188(1):302-10 PubMed
Mol Ecol. 2018 Dec;27(24):5214-5227 PubMed
Nucleic Acids Res. 2011 Jul;39(Web Server issue):W13-7 PubMed
Curr Biol. 1998 Jan 1;8(1):1-10 PubMed
Semin Immunol. 2014 Apr;26(2):145-51 PubMed
J Virol. 2015 Jan;89(1):406-14 PubMed
Nature. 2011 Sep 14;477(7364):289-94 PubMed
Immunol Cell Biol. 2011 Feb;89(2):216-24 PubMed
