Evidence of functional Cd94 polymorphism in a free-living house mouse population
Language English Country United States Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
30535636
DOI
10.1007/s00251-018-01100-x
PII: 10.1007/s00251-018-01100-x
Knihovny.cz E-resources
- Keywords
- Comparative immunology/evolution, Genomics, Inhibitory/activating receptors, MHC, NK cell,
- MeSH
- Alleles MeSH
- Killer Cells, Natural metabolism MeSH
- CD8-Positive T-Lymphocytes metabolism MeSH
- CHO Cells MeSH
- Cricetulus MeSH
- Species Specificity MeSH
- HEK293 Cells MeSH
- Cricetinae MeSH
- NK Cell Lectin-Like Receptor Subfamily C chemistry genetics metabolism MeSH
- NK Cell Lectin-Like Receptor Subfamily D chemistry genetics metabolism MeSH
- Humans MeSH
- Histocompatibility Antigens Class I chemistry genetics metabolism MeSH
- Protein Multimerization MeSH
- Mice, Inbred C57BL MeSH
- Mice, Inbred DBA MeSH
- Peptides chemistry genetics metabolism MeSH
- Polymorphism, Genetic * MeSH
- Amino Acid Sequence MeSH
- Sequence Homology, Amino Acid MeSH
- Protein Binding MeSH
- Animals MeSH
- Check Tag
- Cricetinae MeSH
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Geographicals
- Norway MeSH
- Names of Substances
- NK Cell Lectin-Like Receptor Subfamily C MeSH
- NK Cell Lectin-Like Receptor Subfamily D MeSH
- Histocompatibility Antigens Class I MeSH
- Peptides MeSH
- Q surface antigens MeSH Browser
- Qdm protein, mouse MeSH Browser
The CD94 receptor, expressed on natural killer (NK) and CD8+ T cells, is known as a relatively non-polymorphic receptor with orthologues in humans, other primates, cattle, and rodents. In the house mouse (Mus musculus), a single allele is highly conserved among laboratory strains, and reports of allelic variation in lab- or wild-living mice are lacking, except for deficiency in one lab strain (DBA/2J). The non-classical MHC-I molecule Qa-1b is the ligand for mouse CD94/NKG2A, presenting alternative non-americ fragment of leader peptides (Qa-1 determinant modifier (Qdm)) from classical MHC-I molecules. Here, we report a novel allele identified in free-living house mice captured in Norway, living among individuals carrying the canonical Cd94 allele. The novel Cd94LocA allele encodes 12 amino acid substitutions in the extracellular lectin-like domain. Flow cytometric analysis of primary NK cells and transfected cells indicates that the substitutions prevent binding of CD94 mAb and Qa-1b/Qdm tetramers. Our data further indicate correlation of Cd94 polymorphism with the two major subspecies of house mice in Europe. Together, these findings suggest that the Cd94LocA/NKG2A heterodimeric receptor is widely expressed among M. musculus subspecies musculus, with ligand-binding properties different from mice of subspecies domesticus, such as the C57BL/6 strain.
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