Effect of pallidal deep-brain stimulation on articulation rate in dystonia
Jazyk angličtina Země Itálie Médium print-electronic
Typ dokumentu časopisecké články
Grantová podpora
16-13323S
Grantová Agentura České Republiky
16-19975S
Grantová Agentura České Republiky
15-28038A
Ministerstvo Zdravotnictví Ceské Republiky
CZ.02.1.01/0.0/0.0/16_019/0000765
Research Center for Informatics
PROGRES-Q27/LF1
Ministerstvo Školství, Mládeže a Tělovýchovy
PubMed
30623266
DOI
10.1007/s10072-019-3702-5
PII: 10.1007/s10072-019-3702-5
Knihovny.cz E-zdroje
- Klíčová slova
- Acoustic analysis, Deep-brain stimulation, Dysarthria, Dystonia, Pallidal, Speech,
- MeSH
- dospělí MeSH
- dysartrie etiologie MeSH
- dystonické poruchy terapie MeSH
- globus pallidus * MeSH
- hluboká mozková stimulace škodlivé účinky MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- senioři MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
Pallidal deep-brain stimulation of the internal globus pallidus (GPi-DBS) is an effective treatment for dystonia. However, GPi-DBS may cause important stimulation-induced side effects such as hypokinetic dysarthria, which is particularly manifested by articulation rate abnormalities. However, little data regarding the effect of the location of the electrode and stimulation parameters for pallidal stimulation on articulation rate in dystonia is available. Speech data were acquired from 18 dystonic patients with GPi-DBS and 18 matched healthy controls. Each of dystonic patients was tested twice within 1 day in both the GPi-DBS ON and GPi-DBS OFF stimulation conditions. Compared to healthy controls, the decreased diadochokinetic rate and slower articulation rate in dystonic patients were observed in both stimulation conditions. No significant differences in speech rate measures between stimulation conditions were detected with no relation to contact localization and stimulation intensity. Our findings do not support the use articulation rate as a surrogate marker of stimulation-induced changes to the speech apparatus in dystonia.
Zobrazit více v PubMed
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