Telomere dynamics in adult hematological malignancies
Language English Country Czech Republic Media print-electronic
Document type Journal Article, Review
PubMed
30631211
DOI
10.5507/bp.2018.084
Knihovny.cz E-resources
- Keywords
- aging, hematooncology, leukemia, lymphoma, telomerase, telomere,
- MeSH
- Cell Division MeSH
- Chromosomal Instability genetics MeSH
- Adult MeSH
- Hematologic Neoplasms genetics physiopathology MeSH
- Humans MeSH
- Biomarkers, Tumor metabolism MeSH
- Cellular Senescence genetics physiology MeSH
- Aging genetics physiology MeSH
- Telomerase metabolism MeSH
- Telomere physiology MeSH
- Check Tag
- Adult MeSH
- Humans MeSH
- Publication type
- Journal Article MeSH
- Review MeSH
- Names of Substances
- Biomarkers, Tumor MeSH
- Telomerase MeSH
Telomeres are repetitive DNA sequences protecting physical ends of linear chromosomes against degradation and end-to-end chromosomal fusion. Telomeres shorten with each cell division, which regulates the cellular lifespan in somatic cells and limits their renewal capacity. Cancer cells are often able to overcome this physiological barrier and become immortal with unlimited replicative capacity. In this review, we present current knowledge on the role of telomeres in human aging with a focus on their behavior in hematological malignancies of adults. Associations of telomere length to age-related diseases and to the prevention of telomere shortening are also discussed.
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