Rituximab maintenance overcomes the negative prognostic factor of obesity in CLL: Subgroup analysis of the international randomized AGMT CLL-8a mabtenance trial
Language English Country United States Media print-electronic
Document type Journal Article, Randomized Controlled Trial
PubMed
30888118
PubMed Central
PMC6488104
DOI
10.1002/cam4.1980
Knihovny.cz E-resources
- Keywords
- BMI, CLL, maintenance, obesity, rituximab,
- MeSH
- Survival Analysis MeSH
- Leukemia, Lymphocytic, Chronic, B-Cell drug therapy mortality MeSH
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Obesity complications mortality MeSH
- Prognosis MeSH
- Rituximab administration & dosage therapeutic use MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Maintenance Chemotherapy MeSH
- Treatment Outcome MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Randomized Controlled Trial MeSH
- Names of Substances
- Rituximab MeSH
No data are available regarding obesity and outcome in Chronic Lymphocytic Leukemia (CLL). We analyzed 263 patients from the AGMT CLL-8a Mabtenance trial for the impact of obesity. The trial included patients after rituximab-containing induction treatment in first or second line that had achieved at least a PR. A randomization to rituximab maintenance treatment (375 mg/m2 q3 months for 2 years) vs observation was performed. In this cohort 22% of the patients (58/263) were classified as obese. The baseline response to induction treatment was inferior in obese patients with a lower CR rate (43.1% vs 60.5% in obese vs non-obese, P = 0.018) and with a lower rate of patients achieving MRD negativity after chemoimmunotherapy induction treatment (19.6% vs 35.8%, P = 0.02). The PFS outcome of obese patients was significantly worse in the observation group of the trial (24 vs 39 months median PFS, P = 0.03). However, in the rituximab maintenance group the outcome for obese vs non-obese was not different (P = 0.4). In summary, obesity was overall associated with a worse outcome of chemoimmunotherapy induction. However, rituximab maintenance treatment seems to be able to overcome this negative effect.
3rd Medical Department Paracelsus Medical University Salzburg Salzburg Austria
Assign Data Management and Biostatistics GmbH Innsbruck Austria
Cancer Cluster Salzburg Salzburg Austria
Clinic of Haematology Regional Institute of Oncology Iasi Iasi Romania
Clinic of Hematology UMHAT St George and Medical University Plovdiv Plovdiv Bulgaria
Clinic of Hematology University Hospital St Marina Varna Varna Bulgaria
Clinic of Medical Hematology Military Medical Academy Sofia Sofia Bulgaria
Department of Clinical Hematology FNsP J A Reimana Prešov Prešov Slovakia
Department of Clinical Oncology 1 National Cancer Institute Bratislava Bratislava Slovakia
Department of Hemato oncology 2 National Cancer Institute Bratislava Bratislava Slovakia
Department of Hemato oncology University Hospital Olomouc Olomouc Czech Republic
Department of Hematology and Transfusion University Hospital Martin Martin Slovakia
Department of Hematology FNsP F D Roosevelta Banská Bystrica Banska Bystrica Slovakia
Department of Internal Medicine 3 Kepler Universitätsklinikum GmbH Med Campus 3 Linz Austria
Department of Internal Medicine 4 Klinikum Wels Grieskirchen GmbH Wels Austria
Department of Internal Medicine 5 Medical University Innsbruck Innsbruck Austria
Faculty of Medicine and CEITEC University Hospital Brno Brno Czech Republic
Hematological Clinic NSHATHD Sofia Queen Joanna University Hospital Sofia Bulgaria
Innere Medizin 1 Ordensklinikum Linz GmbH Linz Austria
Innere Medizin 2 Bezirkskrankenhaus Kufstein Kufstein Austria
Innere Medizin Landeskrankenhaus Hall Hall in Tirol Austria
Internal Medicine 2 Hospital of Steyr Steyr Austria
Interne Abteilung Ordensklinikum Linz GmbH Elisabethinen Linz Austria
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